Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells
Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells
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DOI：
10.1038/embor.2013.38
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发表时间：
2013-05-01
期刊：
影响因子：
7.7
通讯作者：
Vieira, Cristina
中科院分区：
文献类型：
--
作者：
Akkouche, Abdou;Grentzinger, Thomas;Vieira, Cristina
转座因子（Transposable elements，TE）在动物生殖腺中被Piwi相互作用RNA（piRNA）沉默，其繁殖可导致宿主基因组的严重损伤。卵巢中产生的piRNA沉积在胚胎生殖系中，并在生殖系后代中启动TE阻遏。然而，母体传递的piRNA是否在体细胞TE的沉默中起作用是未知的。在这里，我们表明，来自果蝇中的tirant逆转录转座子的母系传递的piRNA是TE的体细胞沉默所必需的，并且与组蛋白H3K9三甲基化的增加相关。
Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is however unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required for the somatic silencing of the TE and correlate with an increase in histone H3K9 trimethylation an active tirant copy.