Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin
Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin
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DOI：
10.1093/jac/46.4.621
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发表时间：
2000-10-01
影响因子：
5.2
通讯作者：
Wagner, J
中科院分区：
文献类型：
--
作者：
Arvand, M;Hoeck, M;Wagner, J
通过琼脂稀释法测试了总共 212 株临床化脓性链球菌分离株对各种抗生素的敏感性。红霉素耐药性的总体频率为 12.7%，儿童分离株 (18.9%) 高于成人患者分离株 (10.7%)。克拉霉素也发现了类似的结果，而 2.8% 的分离株对环丙沙星具有耐药性。所有菌株均对青霉素和头孢噻肟敏感。在进行红霉素和克林霉素双盘扩散试验的红霉素耐药分离株中，35%表达对克林霉素的组成型耐药，55%表达诱导型耐药。百分之十的人对克林霉素敏感（M 表型）。因此，柏林的化脓性链球菌对大环内酯类药物的耐药率很高。
A total of 212 clinical Streptococcus pyogenes isolates were tested for susceptibility to various antibiotics by agar dilution. The overall frequency of erythromycin resistance was 12.7%, being higher in isolates from children (18.9%) than in those from adult patients (10.7%). Similar results were found for clarithromycin, while 2.8% of the isolates were resistant to ciprofloxacin. All strains were susceptible to penicillin and cefotaxime. Of the erythromycin-resistant isolates subjected to the double-disc diffusion test for erythromycin and clindamycin, 35% expressed constitutive and 55% inducible resistance to clindamycin. Ten per cent were susceptible to clindamycin (M-phenotype). Thus, a high rate of macrolide resistance in S. pyogenes has emerged in Berlin.