A MORPHOLOGICAL COMPARISON OF FOVEAL DEVELOPMENT IN MAN AND MONKEY
A MORPHOLOGICAL COMPARISON OF FOVEAL DEVELOPMENT IN MAN AND MONKEY
复制标题
DOI：
10.1038/eye.1992.29
复制
发表时间：
1992-01-01
期刊：
影响因子：
3.9
通讯作者：
HENDRICKSON, A
中科院分区：
文献类型：
--
作者：
HENDRICKSON, A
在妊娠26-30%的猴和人的视网膜上，黄斑首先可以被识别为一个包含所有成人视网膜层和仅有视锥感光细胞的区域。在两种动物中，63%-65%的妊娠期都出现了浅凹坑和锥体外节。猴的出生前发育迅速，因此出生时中心凹内有一层视网膜内神经元，视锥细胞有三个细胞深，内节段被拉长，外节长达内节长度的50%。相比之下，人类的中心凹直到出生几个月后才达到类似的阶段。12周的猴子和11-15个月的人的黄斑中心凹类似于成人，尽管人类的黄斑中心凹将进一步成熟到四到五年。这项研究表明，人类的中心凹在出生时不如猴子成熟，但在婴儿期发育迅速，这表明它可能比通常使用的猴子模型更容易受到出生后环境的影响。
The fovea can first be identified in both monkey and human retina at 26-30% gestation as a region containing all adult retinal layers and only cone photoreceptors. A shallow foveal pit and cone outer segments appear by 63-65% gestation in both species. Prenatal development continues rapidly in the monkey, so that by birth a single layer of inner retinal neurons are present in the fovea, cones are three cells deep, inner segments are elongated, and outer segments are up to 50% of inner segment length. In contrast, human fovea does not reach a similar stage until several months after birth. The fovea is adult-like in monkey at 12 weeks and in human at 11-15 months, although human will mature further up to four to five years. This study shows that human fovea is less mature at birth than monkey but develops rapidly in infancy suggesting that it may be even more susceptible to postnatal environmental influences than the commonly-used monkey model.