PLASMA NOREPINEPHRINE, EPINEPHRINE AND CORTICOSTERONE STRESS RESPONSES TO RESTRAINT IN INDIVIDUAL MALE AND FEMALE RATS, AND THEIR CORRELATIONS
PLASMA NOREPINEPHRINE, EPINEPHRINE AND CORTICOSTERONE STRESS RESPONSES TO RESTRAINT IN INDIVIDUAL MALE AND FEMALE RATS, AND THEIR CORRELATIONS
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DOI：
10.1016/0304-3940(85)90283-6
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发表时间：
1985-11-20
影响因子：
2.5
通讯作者：
VOGEL, WH
中科院分区：
文献类型：
--
作者：
LIVEZEY, GT;MILLER, JM;VOGEL, WH
在束缚前和束缚30分钟期间，测定相同雄性和雌性大鼠的去甲肾上腺素（NE）、肾上腺素（E）和皮质酮（C）水平。在NE、E和C内和之间比较个体值。个别大鼠的反应不同的固定和女性通常表现出较高的压力值。NE和E水平上升顺利，同时在所有动物和早期达到峰值。早期（5分钟）NE和E水平，但不是基线值（0分钟），预测的NE和E的应激反应在两种性别的总程度。C反应相对独立于E或NE。男性的C反应，但不是女性的C反应，强烈预测的C5分钟水平，并显着预测的C15分钟水平。此外，与E、NE或女性C反应不同，男性C反应是双相的，在5分钟时显著低于基线，然后在固定结束时（30分钟）上升至峰值水平。
Norepinephrine (NE), epinephrine (E), and corticosterone (C) levels were determined in the same male and female rats before and during a 30-min period of restraint. Individual values were compared within and among NE, E and C. Individual rats responded differently to immobilization and females usually showed higher stress values. NE and E levels rose smoothly and simultaneously in all animals and peaked early. The early (5 min) NE and E levels, but not the baseline values (0 min), predicted the total extent of the NE and E stress responses in both sexes. The C response was relatively independent of either E or NE. The male C response, but not the female C response, was strongly predicted by the C 5-min level, and significantly predicted by the C 15-min level. Additionally, the male C response, unlike the E, NE or female C response, was biphasic, dropping significantly below baseline at 5 min before rising to peak levels at the end of immobilization (30 min).