Shared genetic risk factors in autoimmune liver disease
Shared genetic risk factors in autoimmune liver disease
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DOI：
10.1023/a:1005670111068
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发表时间：
2001-01-01
影响因子：
3.1
通讯作者：
Moore, SB
中科院分区：
文献类型：
--
作者：
Czaja, AJ;Santrach, PJ;Moore, SB
为了确定自身免疫性肝病的共同遗传危险因素是否影响临床表现，我们通过基于DNA的技术评估了271例患者和92例正常人。遗传风险因素在所有条件下都是混合的，并且频率根据疾病类型而变化。DR4可区分自身免疫性肝炎（P = 0.0002）和原发性胆汁性肝硬化（P = 0.004）与原发性硬化性胆管炎。DR52区分原发性硬化性胆管炎与自身免疫性肝炎（P = 0.0007）和原发性胆汁性肝硬化（P = 0.00007），DR3区分自身免疫性肝炎（P = 0.002）和原发性硬化性胆管炎（P = 0.0005）与原发性胆汁性肝硬化。仅原发性硬化性胆管炎组DR4的表达低于正常对照组（P = 0.02）。具有混合遗传风险因素的患者没有明显的特征或表现的混合条件。我们的结论是，具有共同遗传危险因素的患者没有特征性特征，也没有重叠综合征。DR4可能对原发性硬化性胆管炎具有保护作用。
To determine if shared genetic risk factors for autoimmune liver disease affect clinical manifestations, we evaluated 271 patients and 92 normal subjects by DNA-based techniques. Genetic risk factors were intermixed in all conditions, and frequency varied according to disease type. DR4 distinguished autoimmune hepatitis (P = 0.0002) and primary biliary cirrhosis (P = 0.004) from primary sclerosing cholangitis. DR52 distinguished primary sclerosing cholangitis from autoimmune hepatitis (P = 0.0007) and primary biliary cirrhosis (P = 0.00007) and DR3 distinguished autoimmune hepatitis (P = 0.002) and primary sclerosing cholangitis (P = 0.0005) from primary biliary cirrhosis. Only the occurrence of DR4 in primary sclerosing cholangitis was lower than in normal subjects (P = 0.02). Patients with mixed genetic risk factors did not have distinctive features or manifestations of hybrid conditions. We conclude that patients with shared genetic risk factors do not have characteristic features nor do they have overlap syndromes. DR4 may be protective against primary sclerosing cholangitis.