Apoptosis by dietary agents for prevention and treatment of cancer.
Apoptosis by dietary agents for prevention and treatment of cancer.
复制标题
DOI：
10.1016/j.bcp.2008.07.015
复制
发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Mukhtar, Hasan
中科院分区：
文献类型：
--
作者：
Khan, Naghma;Adhami, Vaqar Mustafa;Mukhtar, Hasan
细胞凋亡或程序性细胞死亡在调节多细胞生物体的发育和维持体内平衡中的作用已被充分确立。在过去的十年中，已知在实验模型中产生化学预防作用的天然存在的膳食剂已被证明是靶向糖尿病诱导途径中的信号中间体。细胞凋亡由两种不同的信号触发，一种是主要响应细胞外刺激的外在信号，另一种是由细胞自身内的调节剂激活的内在信号。促细胞凋亡化合物可以通过增强对启动的癌前细胞的消除来防止癌症，而抗细胞凋亡化合物可以通过抑制遗传损伤细胞中的细胞凋亡来促进肿瘤形成。在这篇简短的综述中，我们探讨了各种饮食癌症化学预防成分在细胞凋亡背景下的潜在机制相互作用。
The role of apoptosis or programmed cell death in the regulation of development and maintenance of homeostasis in multicellular organisms is well established. During the last decade, naturally occurring dietary agents known to produce chemopreventive effects in experimental models have been shown to target signaling intermediates in apoptosis-inducing pathways. Apoptosis is triggered by two different signals, one extrinsic, which responds mainly to extracellular stimuli, and the other intrinsic, activated by modulators within the cell itself. Proapoptotic compounds could protect against cancer by enhancing elimination of initiated, precancerous cells, and antiapoptotic compounds could promote tumor formation by inhibiting apoptosis in genetically damaged cells. In this brief review, we explore the potential mechanistic interactions of various dietary cancer chemopreventive components within the context of apoptosis.
登录
查看更多内容
影响因子：
11.5
作者：
Adhami, Vaqar Mustafa;Malik, Arshi;Mukhtar, Hasan
通讯作者：
Mukhtar, Hasan
影响因子：
4.7
作者：
Lazzè, MC;Savio, M;Bianchi, L
通讯作者：
Bianchi, L
影响因子：
7.7
作者：
Alkhalaf, Moussa;El-Mowafy, Abdulla;Al-Attyiah, Rajaa
通讯作者：
Al-Attyiah, Rajaa
影响因子：
5.6
作者：
Larrosa, Mar;Tomas-Barberan, Francisco A.;Espin, Juan Carlos
通讯作者：
Espin, Juan Carlos
影响因子：
4.6
作者：
Mai, Zhiming;Blackburn, George L.;Zhou, Jin-Rong
通讯作者：
Zhou, Jin-Rong