Design and characterizations of novel biodegradable ternary Zn-based alloys with IIA nutrient alloying elements Mg, Ca and Sr
Design and characterizations of novel biodegradable ternary Zn-based alloys with IIA nutrient alloying elements Mg, Ca and Sr
复制标题
具有 IIA 营养合金元素 Mg、Ca 和 Sr 的新型可生物降解三元锌基合金的设计和表征
DOI：
10.1016/j.matdes.2015.05.089
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发表时间：
2015-10-15
影响因子：
8.4
通讯作者：
Wang, Xiang
中科院分区：
文献类型：
--
作者：
Li, Huafang;Yang, Hongtao;Wang, Xiang
锌及锌基合金除了在工业和汽车上的应用外，近年来还被认为是一种有潜力的生物降解材料。然而，纯锌作为潜在的生物降解金属的一个缺点是，纯锌的强度和塑性都很低。在本研究中，三种重要的IIA必需营养元素镁、钙和锶以及热轧和热挤压热变形被用来克服纯锌的缺点，并有利于锌基潜在种植体的生物相容性。对其微观结构、力学性能、腐蚀行为、血液相容性、体外细胞相容性等进行了系统的研究，探讨了其作为生物可吸收植入物的可行性。结果表明，由于合金化效应和热变形效应，三元合金Zn-1 mg-1Ca、Zn-1 mg-1SR和Zn-1Ca-1SR的力学性能均远高于纯锌。体外溶血率试验和细胞活性试验表明，在锌中加入IIA营养合金元素镁、钙和锶有利于其血液相容性和细胞相容性，进一步保证了这些新型可生物降解锌基种植体的生物安全性，为临床应用奠定了基础。(C)2015爱思唯尔有限公司。保留所有权利。
Apart from the industrial and automotive applications, Zn and Zn-based alloys are considered as a new kind of potential biodegradable material quite recently. However, one drawback of pure Zn as potential biodegradable metal lies in that pure Zn has quite low strength and plasticity. In the present study, three important IIA essential nutrient elements Mg, Ca and Sr and hot-rolling and hot-extrusion thermal deformations have been applied to overcome the drawback of pure Zn and benefit the biocompatibility of Zn-based potential implants. The microstructure, mechanical properties, corrosion behavior, hemocompatibility, in vitro cytocompatibility were studied systematically to investigate their feasibility as bioabsorbable implants. The results showed that the mechanical properties of the ternary Zn-1Mg-1Ca, Zn-1Mg-1Sr and Zn-1Ca-1Sr alloys are much higher than that of pure Zn, owing to both the alloying effects and thermal deformation effects. In vitro hemolytic rate test and cell viability test indicated that the addition of the IIA nutrient alloying elements Mg, Ca and Sr into Zn can benefit their hemocompatibility and cytocompatibility, which would further guarantee the biosafety of these new kind of biodegradable Zn-based implants for future clinical applications. (C) 2015 Elsevier Ltd. All rights reserved.