Protease addiction and synthetic lethality in cancer.
Protease addiction and synthetic lethality in cancer.
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DOI：
10.3389/fonc.2011.00025
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发表时间：
2011
影响因子：
4.7
通讯作者：
López-Otín C
中科院分区：
文献类型：
--
作者：
Freije JM;Fraile JM;López-Otín C
“癌基因成瘾”的概念是指癌细胞对癌基因功能的依赖，而“非癌基因成瘾”一词的引入是为了定义非突变基因正常功能的加剧必要性。在这个角度来看，我们专注于蛋白水解酶的重要性，以保持癌细胞的活力，并假设大多数，如果不是全部，肿瘤呈现“成瘾”的一些蛋白水解活性，这反过来可能代表抗癌治疗的有价值的目标，即使没有突变或过表达的恶性细胞。
The “oncogene addiction” concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed phenotype, while the term “non-oncogene addiction” has been introduced to define the exacerbated necessity of the normal function of non-mutated genes. In this Perspective, we focus on the importance of proteolytic enzymes to maintain the viability of cancer cells and hypothesize that most, if not all, tumors present “addiction” to a number of proteolytic activities, which in turn may represent valuable targets of anti-cancer therapies, even without being mutated or over-expressed by the malignant cells.