Expression Profile of MicroRNAs in Epstein-Barr Virus-Infected AGS Gastric Carcinoma Cells
Expression Profile of MicroRNAs in Epstein-Barr Virus-Infected AGS Gastric Carcinoma Cells
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DOI：
10.1128/jvi.02662-13
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发表时间：
2014-01-01
影响因子：
5.4
通讯作者：
Raab-Traub, Nancy
中科院分区：
文献类型：
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作者：
Marquitz, Aron R.;Mathur, Anuja;Raab-Traub, Nancy
EB病毒（EBV）的潜伏感染是多种类型恶性肿瘤的原因，包括10%的胃癌。测定了几种EBV感染的AGS胃癌细胞系中microRNA（miRNA）的表达。感染的细胞以高水平表达病毒BamHI A β转录物（BART）miRNA，并且具有持续降低的一小部分细胞miRNA的表达，同时具有肿瘤抑制miRNA的特异性下调。这些变化可能反映了病毒非编码RNA的表达，而不是潜在的蛋白质表达。
Latent infection with Epstein-Barr virus (EBV) is responsible for multiple types of malignancies, including 10% of all gastric carcinomas. The microRNA (miRNA) expression in several EBV-infected AGS gastric carcinoma cell lines was determined. Infected cells expressed the viral BamHI A rightward transcript (BART) miRNAs at high levels and had consistently decreased expression of a small fraction of cellular miRNAs with specific downregulation of tumor suppressor miRNAs. These changes likely reflect expression of the viral noncoding RNAs and not latent protein expression.