Glycans in post-Golgi apical targeting: sorting signals or structural props?
Glycans in post-Golgi apical targeting: sorting signals or structural props?
复制标题
DOI：
10.1016/s0962-8924(99)01595-0
复制
发表时间：
1999-08
影响因子：
19
通讯作者：
E. Rodriguez-Boulan;Alfonso González
中科院分区：
文献类型：
--
作者：
E. Rodriguez-Boulan;Alfonso González
最近的一个模型提出，n -聚糖通过与反式高尔基网络中的凝集素分选器相互作用，作为上皮细胞和神经元中可溶性蛋白和膜蛋白的顶端靶向信号。然而，我们相信大量的实验观察支持另一种假设，即n -聚糖发挥促进作用，例如通过提供结构支持或防止蛋白质聚集，从而允许蛋白质顶端分选信号与分选机制相互作用。本文讨论了目前可用的实验数据以及它们如何与所提出的模型相关联。
A recent model proposed thatN-glycans serve as apical targeting signals for soluble and membrane proteins in epithelial cells and neurons by interacting with lectin sorters in thetrans-Golgi network. However, we believe that a number of experimental observations support an alternative hypothesis, thatN-glycans play a facilitative role, by providing structural support or preventing aggregation of the proteins for example, thereby allowing interaction of proteinaceous apical sorting signals with the sorting machinery. This article discusses the experimental data currently available and how they relate to the proposed models.