Age-specific incidence of Alzheimer's disease in a community population.
Age-specific incidence of Alzheimer's disease in a community population.
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DOI：
10.1001/jama.1995.03520410048025
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发表时间：
1995-05
期刊：
影响因子：
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通讯作者：
L. Hebert;P. Scherr;Laurel A. Beckett;M. Albert;D. Pilgrim;Marilyn J. Chown;H. Funkenstein;Denis A. Evans
中科院分区：
文献类型：
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作者：
L. Hebert;P. Scherr;Laurel A. Beckett;M. Albert;D. Pilgrim;Marilyn J. Chown;H. Funkenstein;Denis A. Evans
目的确定临床诊断为阿尔茨海默病的年龄别发病率。设计队列，平均跟踪时间为4.3年。背景：马萨诸塞州东波士顿2313名65岁及以上最初没有阿尔茨海默病的人的参与者，1601人参与了事件疾病的确定(80%的幸存者)，409人拒绝参与，303人在随访期结束前死亡。对642人进行了分层抽样，进行了详细的临床评估。结果通过结构化的临床评估，包括神经学、神经心理学和精神病学检查，诊断新的可能的阿尔茨海默病。社区发病率按5岁年龄组计算，并根据性别、单一年龄、随访间隔时间和抽样设计进行调整。结果65~69岁人群阿尔茨海默病年发病率为0.6%(95%可信区间，0.3%~0.9%)，70~74岁人群年发病率为1.0%(95%可信区间，0.6%~1.4%)，75~79岁人群年发病率为2.0%(95%可信区间，1.3%~2.7%)，80~84岁人群年发病率3.3%(95%可信区间，2.2%~4.4%)，85岁及以上人群为8.4%(95%可信区间，3.7%至13.1%)。结论阿尔茨海默病的发病率很高，85岁以上人群的发病率约为65-69岁人群的14倍。
OBJECTIVE To determine age-specific incidence rates of clinically diagnosed Alzheimer's disease. DESIGN Cohort, followed a mean of 4.3 years. SETTING East Boston, Mass. PARTICIPANTS Of 2313 persons aged 65 years and older who were initially free of Alzheimer's disease, 1601 participated in the ascertainment of incident disease (80% of survivors), 409 declined participation, and 303 died before the end of the follow-up period. A stratified sample of 642 persons received detailed clinical evaluation. OUTCOME MEASURE Diagnosis of new probable Alzheimer's disease through structured clinical evaluation including neurologic, neuropsychological, and psychiatric examination. Community incidence rates were computed by 5-year age groups, adjusted for gender, single year of age, length of follow-up interval, and sampling design. RESULTS The estimated annual incidence of Alzheimer's disease in the population was 0.6% (95% confidence interval [CI], 0.3% to 0.9%) for persons aged 65 to 69 years, 1.0% (95% CI, 0.6% to 1.4%) for persons aged 70 to 74 years, 2.0% (95% CI, 1.3% to 2.7%) for persons aged 75 to 79 years, 3.3% (95% CI, 2.2% to 4.4%) for persons aged 80 to 84 years, and 8.4% (95% CI, 3.7% to 13.1%) for persons aged 85 years and older. CONCLUSIONS The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age.