Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease - The San Antonio Heart Study
Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease - The San Antonio Heart Study
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DOI：
10.2337/diacare.25.7.1177
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发表时间：
2002-07-01
期刊：
影响因子：
16.2
通讯作者：
Haffner, SM
中科院分区：
文献类型：
--
作者：
Hanley, AJG;Williams, K;Haffner, SM
目的 - 胰岛素水平与心血管疾病 (CVD) 风险之间的前瞻性关联存在争议，本研究的目的是在圣安东尼奥心脏研究的 8 年随访中，调查胰岛素抵抗稳态模型评估 (HOMA-IR) 以及胰岛素水平与非致命性和致命性 CVD 风险的关系。 研究设计和方法 - 1984 年至 1988 年间，随机选择墨西哥裔美国人和圣安东尼奥市的非西班牙裔白人居民参加了基线检查，包括空腹血液样本的葡萄糖、胰岛素和血脂、葡萄糖耐量测试、人体测量和生活方式调查问卷。 199 1 至 1996 年间，使用相同的方案对 2,569 名基线时没有糖尿病的受试者进行了重新检查。 结果 - 在随访期间，187 名受试者经历了心血管事件（心脏病发作、中风、心脏手术、心绞痛或 CVD 死亡）。 Logistic 回归分析表明，在调整年龄、性别和种族后，CVD 事件的风险在 HOMA-IR 五分位数中增加（P 为趋势）
OBJECTIVE - The prospective association between insulin levels and risk of cardiovascular disease (CVD) is controversial, The objective of the present Study Was to investigate the relationship of the homeostasis model assessment of insulin resistance (HOMA-IR), as well as insulin levels, with risk of nonfatal and Fatal CVD over the 8-year follow-up of the San Antonio Heart Study.RESEARCH DESIGN AND METHODS - Between 1984 and 1988, randomly selected Mexican-American and non-Hispanic white residents of San Antonio participated in baseline examinations that included fasting blood samples for glucose, insulin, and lipids, a glucose tolerance test, anthropometric measurements, and a lifestyle questionnaire. Between 199 1 and 1996, 2,569 subjects who were free of diabetes at baseline were reexamined using the same protocol.RESULTS - Over the follow-up period, 187 subjects experienced an incident cardiovascular event (heart attack, stroke, heart surgery, angina, or CVD death). Logistic regression analysis indicated that risk of a CVD event increased across quintiles of HOMA-IR after adjustment for age, sex, and ethnicity (P for trend