Fat and meat intake and prostate cancer risk: The Multiethnic Cohort Study
Fat and meat intake and prostate cancer risk: The Multiethnic Cohort Study
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DOI：
10.1002/ijc.22805
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发表时间：
2007-09-15
影响因子：
6.4
通讯作者：
Kolonel, Laurence N.
中科院分区：
文献类型：
--
作者：
Park, Song-Yi;Murphy, Suzanne P.;Kolonel, Laurence N.
膳食脂肪和肉类作为前列腺癌的潜在危险因素一直是许多流行病学调查的焦点，特别是最近的研究结果并不一致。因此，我们在多种族队列研究中检查了这些暴露与前列腺癌风险之间的关系。研究分析了82483名年龄在45岁的夏威夷和洛杉矶男性，他们在1993-1996年间完成了一份详细的定量食物频率调查问卷。在8年的随访期间，共发现4404例病例，其中包括1278例非局限性或高级别癌症病例。采用Cox比例风险模型，在调整研究时间、种族、前列腺癌家族史、教育程度、体重指数、吸烟状况和能量摄入后，估计前列腺癌的相对风险。摄入不同类型的脂肪（总脂肪、饱和脂肪、单不饱和脂肪或多不饱和脂肪）、n-6脂肪酸、胆固醇、各种肉类和肉类脂肪与前列腺癌的总体风险、非局限性前列腺癌或高度前列腺癌没有关联。此外，我们发现在4个种族/民族群体（非裔美国人、日裔美国人、拉丁美洲人和白人）中，几乎没有证据表明脂肪和肉类摄入量与前列腺癌风险有任何关系。研究表明，n-3脂肪酸的摄入有保护作用，但仅限于拉丁裔和白人。然而，总的来说，我们对不同种族人群进行的大型队列研究发现，没有迹象表明脂肪和肉类的摄入会显著影响前列腺癌的风险。(c) 2007 Wiley-Liss, Inc。
Dietary fat and meat as potential risk factors for prostate cancer have been the focus of many epidemiologic investigations, and findings from recent studies in particular have been inconsistent. Therefore, we examined the association between these exposures and prostate cancer risk in the Multiethnic Cohort Study. The analyses included 82,483 men in Hawaii and Los Angeles aged >= 45, who completed a detailed quantitative food frequency questionnaire in 1993-1996. During the follow-up period of 8 years, a total of 4,404 incident cases, including 1,278 nonlocalized or high-grade cancer cases, were identified. Cox proportional hazard models were used to estimate relative risks of prostate cancer after adjustment for time on study, ethnicity, family history of prostate cancer, education, body mass index, smoking status and energy intake. Intake of different types of fat (total, saturated, monounsaturated or polyunsaturated), n-6 fatty acid, cholesterol, various meats, and fats from meat showed no association with overall prostate cancer risk or with nonlocalized or high-grade prostate cancer. Furthermore, we found little evidence of any relation of fat and meat intake with prostate cancer risk within any of the 4 racial/ethnic groups (African Americans, Japanese Americans, Latinos and Whites). There was a suggestion of a protective effect of n-3 fatty acid intake that was limited to Latinos and Whites. However, overall, our findings from a large cohort study of ethnically diverse population give no indication that intake of fat and meat substantially affects prostate cancer risk. (c) 2007 Wiley-Liss, Inc.