Enhanced antibody responses to Epstein-Barr virus in HIV-infected homosexual men.
Enhanced antibody responses to Epstein-Barr virus in HIV-infected homosexual men.
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感染艾滋病毒的同性恋男性对 Epstein-Barr 病毒的抗体反应增强。
DOI：
10.1093/infdis/159.3.472
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
RinaldoJr,CR
中科院分区：
文献类型：
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作者：
Rahman,MA;Kingsley,LA;Breinig,MK;Ho,M;Armstrong,JA;Atchison,RW;Lyter,DW;RinaldoJr,CR
我们调查了 593 名同性恋男性中人类免疫缺陷病毒 (HIV) 和 Epstein-Barr 病毒 (EBV) 感染之间的关联。该组的 EBV 感染状况是根据 EBV 特异性抗体反应的血清学证据进行评估的。 141 名 HIV 血清阳性男性中的 EBV 衣壳抗原 (EBV-VCA) (1:154) 和 EBV 早期抗原 (EA) (1:16) 抗体几何平均滴度 (GMT) 显着高于 452 名 HIV 血清阴性男性中的相应滴度（1:95 和 1:12）。患有淋巴结病的 HIV 感染男性的 EBV 抗体滴度高于无症状的 HIV 血清阳性男性。然而，这些相关性在患有艾滋病相关综合症的患者中不太明显。发现 EBV 抗体滴度升高与总血清 IgG 水平无关。研究还发现，HIV 血清阳性男性的巨细胞病毒 (CMV) 抗体滴度显着升高，与总 IgG 无关。无论是 HIV 血清阴性还是 HIV 血清阳性男性，EBV 抗体滴度与 CMV 抗体滴度均不相关。没有 HIV 感染证据但 EBV-VCA 和 EBV-EA 抗体滴度较高的受试者，与 EBV 抗体滴度较低的受试者相比，CD3+、CD4+ 和 CD8+ 细胞的平均数量较高，CD4+/CD8+ 细胞比率水平较低。这项研究表明，同性恋男性中 EBV 循环抗体水平升高与 HIV 感染导致的潜伏 EBV 失控有关。
We investigated the association between human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) infections in 593 homosexual men. The status of EBV infection in this group was evaluated based on serological evidence of EBV-specific antibody responses. The geometric mean titers (GMT) of antibody to EBV capsid antigen (EBV-VCA) (1:154) and EBV early antigen (EA) (1:16) in 141 HIV-seropositive men were significantly higher than respective titers in 452 HIV seronegative men (1:95 and 1:12). Antibody titers to EBV were higher in HIV-infected men with lymphadenopathy than in asymptomatic HIV-seropositive men. However, these correlation were less evident in patients with AIDS-related complex. Elevated antibody titers to EBV were found to be independent of levels of total serum IgG. Cytomegalovirus (CMV) antibody titers were also found to be significantly increased among HIV-seropositive men, independent of total IgG. Antibody titers to EBV were not correlated with those to CMV in either HIV-seronegative or HIV-seropositive men. Subjects without evidence of HIV infection, but who had high antibody titers to EBV-VCA and EBV-EA, had elevated mean numbers of CD3+, CD4+, and CD8+ cells, and lower levels of CD4+/CD8+ cell ratios compared to subjects with low EBV-antibody titers. This study suggests that the elevated levels of circulating antibodies against EBV in homosexual men are associated with loss of control of latent EBV due to HIV infection.