The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice.
The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice.
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DOI：
10.1007/s12265-021-10147-3
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Jiang X;Li H;Liu Y;Bao L;Zhan L;Gao H;Deng W;Xue J;Liu J;Liu X;Li J;Wang J;Wu S;Yan M;Luo W;Jose PA;Qin C;Yang X;Zhang D;Yang Z
血管紧张素转换酶2（ACE 2）是严重急性呼吸综合征冠状病毒2型进入细胞所必需的。ACE 2通过Ang-（1-7）-Mas-R轴，是肾素-血管紧张素系统的抗高血压和心脏保护作用的一部分。我们研究了患有高血压的住院COVID-19患者和高血压人类（h）ACE 2转基因小鼠，以确定COVID-19在有或没有AT 1受体（AT 1 R）阻断剂治疗的情况下的结果。接受AT 1 R阻滞剂治疗的高血压COVID-19患者的疾病严重程度和血清心脏生物标志物（CK、CK-BM、cTnI）以及炎症标志物（IL-1、IL-6、CRP）水平低于接受其他降压药物治疗的患者。用AT 1 R阻断剂预处理的高血压hACE 2转基因小鼠在感染后1天肾脏和心脏中ACE 2表达和SARS-CoV-2增加。我们的结论是，这些高血压患者治疗AT 1 R阻滞剂可能是在较高的风险，SARS冠状病毒-2感染。然而，AT 1 R阻滞剂对疾病的严重程度没有影响，反而可能通过ACE 2-血管紧张素1 -7-Mas受体轴保护COVID-19患者免受心脏损伤。在线版本包含补充材料，可通过10.1007/s12265-021-10147-3获得。
Angiotensin-converting enzyme 2 (ACE2) is required for the cellular entry of the severe acute respiratory syndrome coronavirus 2. ACE2, via the Ang-(1-7)-Mas-R axis, is part of the antihypertensive and cardioprotective effects of the renin-angiotensin system. We studied hospitalized COVID-19 patients with hypertension and hypertensive human(h) ACE2 transgenic mice to determine the outcome of COVID-19 with or without AT1 receptor (AT1R) blocker treatment. The severity of the illness and the levels of serum cardiac biomarkers (CK, CK-BM, cTnI), as well as the inflammation markers (IL-1, IL-6, CRP), were lesser in hypertensive COVID-19 patients treated with AT1R blockers than those treated with other antihypertensive drugs. Hypertensive hACE2 transgenic mice, pretreated with AT1R blocker, had increased ACE2 expression and SARS-CoV-2 in the kidney and heart, 1 day post-infection. We conclude that those hypertensive patients treated with AT1R blocker may be at higher risk for SARS-CoV-2 infection. However, AT1R blockers had no effect on the severity of the illness but instead may have protected COVID-19 patients from heart injury, via the ACE2-angiotensin1-7-Mas receptor axis. The online version contains supplementary material available at 10.1007/s12265-021-10147-3.
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影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
影响因子：
24
作者：
Inciardi, Riccardo M.;Lupi, Laura;Metra, Marco
通讯作者：
Metra, Marco
影响因子：
158.5
作者：
Mancia, Giuseppe;Rea, Federico;Corrao, Giovanni
通讯作者：
Corrao, Giovanni
DOI：
10.1136/heartjnl-2020-317393
发表时间：
2020-10
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Hippisley-Cox J;Young D;Coupland C;Channon KM;Tan PS;Harrison DA;Rowan K;Aveyard P;Pavord ID;Watkinson PJ
通讯作者：
Watkinson PJ
影响因子：
8.3
作者：
Iaccarino, Guido;Grassi, Guido;Volpe, Massimo
通讯作者：
Volpe, Massimo