SPATIO-TEMPORAL CORRELATES OF TASTE PROCESSING IN THE HUMAN PRIMARY GUSTATORY CORTEX
SPATIO-TEMPORAL CORRELATES OF TASTE PROCESSING IN THE HUMAN PRIMARY GUSTATORY CORTEX
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DOI：
10.1016/j.neuroscience.2014.05.017
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发表时间：
2014-07-25
期刊：
影响因子：
3.3
通讯作者：
Schoenfeld, A. M.
中科院分区：
文献类型：
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作者：
Iannilli, E.;Noennig, N.;Schoenfeld, A. M.
在人类中，初级味觉皮层（PGC）的鉴定仍然存在争议。神经影像学研究表明，脑岛和上盖是最佳的候选者，但PGC在该区域的确切位置尚不完全清楚。此外，当比较使用功能磁共振成像（fMRI）和味觉事件相关电位（gERP）或味觉事件相关磁场（gERMF）的研究结果时，会出现不一致。fMRI显示脑岛前部和额叶盖层激活，而gERP和/或gERMF显示脑岛后部顶盖盖层与脑岛之间的过渡区激活。这里需要注意的是，对于gERP和gERMF，刺激的时间和空间特征必须得到很好的控制，以引起有用的大脑反应。在本研究中，gERMF和gERP分别使用249个磁力计和32个电极的全头系统同时记录；味觉刺激使用的刺激器提供了良好的时间和空间控制的刺激。单独的ERP和ERMF平均波形被导出到味觉刺激开始的时间锁定。对早期时间范围的源分析显示，活动在左、右脑岛前部和中部，而在较晚的时间范围内，源更多地位于脑岛后部。(c) 2014 ibro。Elsevier Ltd.出版。版权所有。
In humans the identification of the primary gustatory cortex (PGC) is still under debate. Neuroimaging studies indicate insula and overlying opercula as the best candidates but the exact position of the PGC within this region is not entirely clear. Moreover, inconsistencies appear when comparing results from studies using functional magnetic resonance imaging (fMRI), and gustatory event-related potentials (gERP), or gustatory event-related magnetic fields (gERMF). fMRI indicates activations in the anterior part of the insula and frontal operculum, while gERP and/or gERMF indicate activations at the transition between the parietal operculum and insula in its posterior part. Here it is important to note that for gERP and gERMF temporal and spatial characteristics of the stimulus must be well controlled to evoke a useful brain response. In the present study gERMF and gERP were recorded simultaneously using a whole-head system with 249 magnetometers and 32 electrodes, respectively; taste stimuli were applied using a stimulator providing excellent temporal and spatial control of the stimulus. Separate ERP and ERMF averaged waveforms were derived time-locked to the onset of the taste stimuli. The source analysis for the early time range revealed activity in the left and right anterior and mid part of the insula, where in the later time range the sources were located more in the posterior part of the insula. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.