Three Indonesian clusters of H5N1 virus infection in 2005
Three Indonesian clusters of H5N1 virus infection in 2005
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DOI：
10.1056/nejmoa060930
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发表时间：
2006-11-23
影响因子：
158.5
通讯作者：
Uyeki, Timothy M.
中科院分区：
文献类型：
--
作者：
Kandun, I. Nyoman;Wibisono, Hariadi;Uyeki, Timothy M.
背景：自2003年以来，在家禽和鸟类中持续广泛流行的甲型H5N1禽流感已在10个国家造成人间H5N1病例。2005年7月在印度尼西亚发现了第一例H5N1病毒感染病例。方法：我们调查了2005年6月至10月期间印度尼西亚发生的三起聚集性病例，其中至少有两名患者因H5N1病毒感染的实验室证据而住院。收集并分析了这些患者的流行病学、临床和病毒学资料。结果：3例病例均发生重症，其中2例死亡。儿童轻度疾病分为两组。8例患者的中位年龄为8.5岁（范围1 - 38岁）。4例患者需要机械通气，8例患者中4例（50%）死亡。在每个聚集性病例中，H5N1病毒感染患者均为同一家庭成员，且多数生活在同一家庭。在两个聚集性病例中，未确定指示患者的H5N1病毒感染源。在两个聚集性病例中，每一名患者均可获得病毒分离株，分子序列分析确定分离株为禽源的2枝H5N1病毒。结论：2005年在印度尼西亚，人感染2枝H5N1病毒的聚集性病例包括家庭成员中的轻度、重度和致命病例。
Background: Since 2003, the widespread ongoing epizootic of avian influenza A (H5N1) among poultry and birds has resulted in human H5N1 cases in 10 countries. The first case of H5N1 virus infection in Indonesia was identified in July 2005.Methods: We investigated three clusters of Indonesian cases with at least two ill persons hospitalized with laboratory evidence of H5N1 virus infection from June through October 2005. Epidemiologic, clinical, and virologic data on these patients were collected and analyzed.Results: Severe disease occurred among all three clusters, including deaths in two clusters. Mild illness in children was documented in two clusters. The median age of the eight patients was 8.5 years (range, 1 to 38). Four patients required mechanical ventilation, and four of the eight patients (50%) died. In each cluster, patients with H5N1 virus infection were members of the same family, and most lived in the same home. In two clusters, the source of H5N1 virus infection in the index patient was not determined. Virus isolates were available for one patient in each of two clusters, and molecular sequence analyses determined that the isolates were clade 2 H5N1 viruses of avian origin.Conclusions: In 2005 in Indonesia, clusters of human infection with clade 2 H5N1 viruses included mild, severe, and fatal cases among family members.