Fast-forward playback of recent memory sequences in prefrontal cortex during sleep
Fast-forward playback of recent memory sequences in prefrontal cortex during sleep
复制标题
DOI：
10.1126/science.1148979
复制
发表时间：
2007-11-16
期刊：
影响因子：
56.9
通讯作者：
McNaughton, Bruce L.
中科院分区：
文献类型：
--
作者：
Euston, David R.;Tatsuno, Masami;McNaughton, Bruce L.
正如先前在海马和其他大脑区域中所显示的那样，在重复序列任务期间大鼠内侧前额叶皮层神经元之间的放电频率相关性模式在随后的睡眠中被保留下来，这表明清醒模式被重新激活。我们发现，在睡眠期间，时空模式的重新激活在整个网络中是一致的，并且在时间上被压缩了6到7倍。因此，当行为约束被移除时，大脑的内在处理速度可能比真实的时间快得多。鉴于最近的证据表明，内侧前额叶皮层在检索长期记忆，所观察到的重放可能在记忆巩固的过程中发挥作用。
As previously shown in the hippocampus and other brain areas, patterns of firing-rate correlations between neurons in the rat medial prefrontal cortex during a repetitive sequence task were preserved during subsequent sleep, suggesting that waking patterns are reactivated. We found that, during sleep, reactivation of spatiotemporal patterns was coherent across the network and compressed in time by a factor of 6 to 7. Thus, when behavioral constraints are removed, the brain's intrinsic processing speed may be much faster than it is in real time. Given recent evidence implicating the medial prefrontal cortex in retrieval of long-term memories, the observed replay may play a role in the process of memory consolidation.