The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimXCdc2
The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimXCdc2
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DOI：
10.1016/s0014-5793(02)02964-2
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发表时间：
2002-07
期刊：
影响因子：
3.5
通讯作者：
Niklas Schier;R. Fischer
中科院分区：
文献类型：
--
作者：
Niklas Schier;R. Fischer
The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimXCdc2and a G1/S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimXCdc2. We propose that PclA modulates the kinase activity of NimXCdc2during spore formation.
