C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats
C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats
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C19 是趋化因子样因子 1 的 C 端肽，可保护大脑免受大鼠局灶性脑缺血的影响
DOI：
10.1016/j.neulet.2011.11.048
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发表时间：
2012-02-02
影响因子：
2.5
通讯作者：
Chen, Nai-Hong
中科院分区：
文献类型：
--
作者：
Kong, Ling-Lei;Hu, Jin-Feng;Chen, Nai-Hong
越来越多的证据表明趋化因子在脑缺血中起重要作用。趋化因子样因子1（CKLF 1）作为一种新的C-C趋化因子，在脑缺血时表达上调。在这项研究中，我们研究了C19，趋化因子样因子1的C-末端肽，在脑缺血动物模型的保护作用。成年大鼠用水合氯醛麻醉。大脑中动脉阻断60 min后立即侧脑室注射C19。再灌注24 h后检测动物的神经功能、梗死面积和含水量。结果表明，C19（0.1、1、10、50 μ g）能明显改善神经功能，并呈剂量依赖性地减小脑梗死面积和脑含水量。相反，应用C19（50 μ g）对正常大鼠没有影响。综上所述，我们的数据表明，C19对缺血性脑损伤具有保护作用，可能是治疗脑缺血的理想肽类药物。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
There has been accumulating evidence that chemokines play an important role in cerebral ischemia. Chemokines-like factor 1 (CKLF1), as a novel C-C chemokine, is upregulated in cerebral ischemia. In this study we examined the protective effect of C19, a C-terminal peptide of chemokine-like factor 1, in an animal model of cerebral ischemia. Adult rats were anesthetized with chloral hydrate. C19 was given intracerebroventricularly immediately after 60 min middle cerebral artery occlusion. Animals were examined for their neurological function, infarct size and water content at 24 h after reperfusion. The result showed that C19 (0.1, 1,10 or 50 mu g) significantly improved neurological function, decreased infarct size and water content in a dose-dependent manner. In contrast, application of C19 (50 mu g) showed no effect in normal rats. Taken together, our data suggest that C19 is protective against ischemic brain injury, and may be an ideal peptide drug for the treatment of cerebral ischemia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.