The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)
The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)
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OX40 在免疫介导的胃肠道疾病（乳糜泻、克罗恩病、溃疡性结肠炎）中的表达
DOI：
10.1046/j.1365-2362.2000.00658.x
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发表时间：
2000
影响因子：
5.5
通讯作者：
U. Fölsch
中科院分区：
文献类型：
--
作者：
E. Stüber;A. Büschenfeld;J. Lüttges;A. Freier;T. Arendt;U. Fölsch
膜结合受体OX 40（CD 134）-TNF-R/NGF-R超家族的成员-在人类和啮齿动物的活化CD 4 +-T细胞上表达。OX 40与其配体（OX 40 L）的相互作用已被证明在体外和体内T细胞依赖性B细胞刺激和T细胞共刺激中是重要的。在免疫介导的胃肠道疾病的实验动物模型中进行的几项研究强调了OX 40-OX 40 L相互作用对其表现的重要作用。为了评估OX 40-OX 40 L相互作用是否在免疫介导的人胃肠道疾病（例如乳糜泻、克罗恩病、溃疡性结肠炎）的发病机制中也是至关重要的，我们在第一系列实验中研究了OX 40在患有这些疾病的患者的活检样本中的表达。
The membrane bound receptor OX40 (CD134) — a member of the TNF‐R/NGF‐R superfamily — is expressed on activated CD4+‐T cells in humans and rodents. The interaction of OX40 with its ligand (OX40L) has been shown to be important in T‐cell dependent B cell‐stimulation and T‐cell costimulation in vitro and in vivo. Several studies in experimental animal models for immunologically mediated GI‐diseases have stressed the important role of the OX40–OX40L interaction for their manifestations. To assess if the OX40–OX40L interaction is also crucial in the pathogenesis of immunologically mediated diseases of the human gastrointestinal tract (e.g. celiac disease, Crohn's disease, ulcerative colitis) we investigated, in a first line of experiments, the expression of OX40 in biopsy specimens of patients suffering from these diseases.
影响因子：
4.4
作者：
D. Calderhead;J. Buhlmann;A. V. D. van den Eertwegh;E. Claassen;R. Noelle;H. P. Fell
通讯作者：
D. Calderhead;J. Buhlmann;A. V. D. van den Eertwegh;E. Claassen;R. Noelle;H. P. Fell