Regulation of estrogen synthesis in postmenopausal women
Regulation of estrogen synthesis in postmenopausal women
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DOI：
10.1016/s0039-128x(02)00046-6
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发表时间：
2002-11-01
期刊：
影响因子：
2.7
通讯作者：
Reed, MJ
中科院分区：
文献类型：
--
作者：
Purohit, A;Reed, MJ
绝经期卵巢雌激素分泌的减少可能导致外周芳香酶活性的增加。虽然雌激素对骨骼和心血管系统等身体组织有益，但它们在促进乳腺肿瘤的生长和发展方面也起着至关重要的作用。许多因子，包括白细胞介素-6 （IL-6）、肿瘤坏死因子α (TNFalpha)和前列腺素E-2 (PGE(2))，可以刺激芳香化酶的活性，现在已经被确定。由于一些细胞因子的血浆浓度在更年期增加，这可能解释了在老年妇女中检测到的外周芳香酶活性增加的原因。浸润乳腺组织的巨噬细胞和淋巴细胞现在被认为是细胞因子的重要来源，细胞因子可以刺激乳腺组织中的芳香酶活性。我们最近进行的研究表明，内源性雌激素代谢物2-甲氧基雌二醇可能能够调节细胞因子和PGE(2)刺激芳香酶活性的能力。了解内源性雌激素代谢物在调节雌激素合成中的作用可能会为预防或治疗乳腺癌提供新的策略。(C) 2002爱思唯尔科学有限公司版权所有。
The decrease in ovarian estrogen production that occurs at the menopause may lead to an increase in peripheral aromatase activity. While estrogens can have beneficial effects on some body tissues, such as bone and the cardiovascular system, they also have a crucial role in supporting the growth and development of breast tumors. A number of factors, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and prostaglandin E-2 (PGE(2)), which can stimulate aromatase activity, have now been identified. As plasma concentrations of some cytokines increase at the menopause, this may account for the increased peripheral aromatase activity that is detected in older women. Macrophages and lymphocytes which infiltrate breast tissue are now thought to be an important source of cytokines that can stimulate aromatase activity in this tissue. Studies, we have recently carried out, have suggested that the endogenous estrogen metabolite, 2-methoxy-estradiol, may be able to modulate the ability of cytokines and PGE(2) to stimulate aromatase activity. Understanding the role of endogenous estrogen metabolites in regulating estrogen synthesis may give rise to new strategies for the prevention or treatment of breast cancer. (C) 2002 Elsevier Science Inc. All rights reserved.