Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans.
Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans.
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DOI：
10.1016/j.jcv.2009.06.006
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Guan Y
中科院分区：
文献类型：
--
作者：
Peiris JS;Poon LL;Guan Y
最近出现的一种新型甲型H1N1流感病毒继续在全球传播。该病毒包含一组新的基因片段，已知最接近的前体是在猪中发现的病毒，它可能是通过两种或多种猪源病毒的重配而产生的。H1N1、H1 N2和H3 N2亚型猪流感病毒以前偶尔感染过人类，但这种人畜共患传播事件并没有像这种猪源流感病毒（S-OIV）那样导致持续的人传人。它在人类中的传播似乎高于季节性流感。儿童和年轻人似乎是受影响最严重的人，也是那些似乎保持传播的人。临床疾病通常表现为轻度，但可能发生导致住院治疗的并发症，特别是在患有潜在肺部或心脏疾病、糖尿病或接受免疫抑制治疗的患者中。有人担心该病毒可能与现有的人类流感病毒重组，产生更具传播性或更具致病性的病毒。该病毒似乎保留了传播回猪的潜力，因此与猪病毒的持续重配是一个值得关注的问题。
A recently emerged novel influenza A H1N1 virus continues to spread globally. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it likely arose through reassortment of two or more viruses of swine origin. H1N1, H1N2 and H3N2 subtype swine influenza viruses have occasionally infected humans before but such zoonotic transmission-events did not lead to sustained human-to-human transmission in the manner this swine-origin influenza virus (S-OIV) has done. Its transmission among humans appears to be higher than that observed with seasonal influenza. Children and young adults appear to those most affected and also those who appear to maintain transmission. Clinical disease generally appears mild but complications leading to hospitalization can occur, especially in those with underlying lung or cardiac disease, diabetes or those on immunosuppresive therapies. There are concerns that the virus may reassort with existing human influenza virus giving rise to more transmissible or more pathogenic viruses. The virus appears to retain the potential to transmit back to swine and thus continued reassortment with swine viruses is a cause for concern.