A FETAL TYPE OF MINAMATA DISEASE - AN AUTOPSY CASE-REPORT WITH SPECIAL REFERENCE TO THE NERVOUS-SYSTEM
A FETAL TYPE OF MINAMATA DISEASE - AN AUTOPSY CASE-REPORT WITH SPECIAL REFERENCE TO THE NERVOUS-SYSTEM
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DOI：
10.1007/bf03159968
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发表时间：
1992-02-01
期刊：
影响因子：
--
通讯作者：
SUDA, I
中科院分区：
文献类型：
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作者：
ETO, K;OYANAGI, S;SUDA, I
我们的知识有关的病理胎儿的情况下，人类水俣病（甲基汞中毒）是相对有限的。本文报告一例1957年出生，体重3000克，于1987年死亡的女性汞中毒患者，经29年生存后，其全身各器官汞的分布及神经系统超微结构的改变。她被诊断为脑瘫，并在3岁时发生惊厥。1959年检查时，她母亲头发中的汞含量为101微克/克。尸检时，尸体长43厘米，重23公斤。大脑重920 g，显示明显的脑萎缩，距状核、中央后和中央前皮质轻度神经元丢失，小脑萎缩和外周神经节段性脱髓鞘。汞颗粒存在于脑、肾和肝中。距状核、中央后和中央前皮质和小脑皮质的超微结构检查显示神经细胞严重萎缩，粗面内质网减少，核染色质增加，线粒体保存完好。自噬体数量增加。此外，在大脑和小脑神经元内还发现了高电子密度的球状致密体，直径为0.3-1.8 μ m，周围被有限的膜所包围。在小脑中，突触保存完好。
Our knowledge concerning the pathology of fetal cases of human Minamata disease (methylmercury poisoning) is relatively limited. We report here a case with description of the distribution of mercury in the systemic organs, and the ultrastructural changes of the nervous system after a survival of 29 yr.The patient was a female born in 1957, with a body wt of 3000 g, who died in 1987. She carried a diagnosis of cerebral palsy, and had a convulsion at age 3 yr. Mercury levels in her mother's hair were 101 mu-g/g at the time of examination in 1959.At autopsy, the body measured 43 cm and weighed 23 kg. The brain weighed 920 g and showed marked cerebral atrophy, mild neuronal loss in the calcarine, postcentral and precentral cortices, cerebellar atrophy, and segmental demyelination of peripheral nerves. Mercury granules were present in the brain, kidney, and liver.Ultrastructural examination of the calcarine, post- and precentral cortices, and cerebellar cortices, showed severe atrophy of nerve cells, with a decrease in rough ER and an increase in nuclear chromatin and preservation of mitochondria.Autophagosomes were increased in number. In addition, high electron density, globular and dense bodies, measuring 0.3-1.8-mu-m in diameter, were found, surrounded by limited membrane, within both cerebral and cerebellar neurons. In the cerebellum, synapses were well-preserved.