Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections
Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections
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DOI：
10.1111/j.1469-0691.2005.01230.x
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发表时间：
2005-10-01
影响因子：
14.2
通讯作者：
Bjornholt, JV
中科院分区：
文献类型：
--
作者：
Berdal, JE;Skråmm, I;Bjornholt, JV
人工关节感染难以根除，抗生素和手术治疗策略缺乏标准化。本研究随访了29例早期人工关节感染患者（中位年龄72岁，美国麻醉学会评分中位数为2）。治疗包括器械保留、手术清创和利福平和环丙沙星治疗3个月。在研究期间，这种治疗方案在5名患者中失败，中位观察期为674天。本研究的结果证实了之前唯一一项关于抗生素治疗器械固位的研究结果。
Prosthetic joint infections are difficult to eradicate, and antibiotic and surgical treatment strategies lack standardisation. The present study followed 29 patients (median age 72 years, median American Society of Anesthesia score of two) with early prosthetic joint infections. Treatment consisted of device retention, surgical debridement and therapy with rifampicin and ciprofloxacin for 3 months. This treatment regimen failed in five patients during the study, with a median observation period of 674 days. The results of this study confirm the findings of the only previous study on device retention with antibiotic treatment.