Tobacco use, body mass index and the risk of malignant lymphomas - A nationwide cohort study in Sweden
Tobacco use, body mass index and the risk of malignant lymphomas - A nationwide cohort study in Sweden
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DOI：
10.1002/ijc.21617
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发表时间：
2006-05-01
影响因子：
6.4
通讯作者：
Adami, J
中科院分区：
文献类型：
--
作者：
Fernberg, P;Odenbro, A;Adami, J
在寻找淋巴组织增生性恶性肿瘤病因学中的危险因素时，关于吸烟的影响仍然存在不一致的证据，无烟烟草的作用也没有得到充分的研究。新的证据表明，超重会增加NHL和HD的风险。为了确定各种形式的烟草使用和高体重指数（BMI）是否会影响这些肿瘤的发生，我们对建筑业工作环境和健康计划中的33万多名瑞典建筑工人进行了前瞻性队列研究。吸烟，鼻烟蘸，身高和体重的信息收集自填问卷连同个人访谈。通过与瑞典全国癌症登记处、移民登记处和死因登记处的记录联系，确定了2000年的癌症发病率。随访结束时，分别有1，309例受试者被诊断为NHL（包括慢性淋巴细胞白血病）和205例HD。使用考克斯比例风险回归模型计算年龄校正的发生率比。吸烟、烟斗或雪茄与NHI或HI无关。没有证据表明吸烟量和持续时间与NHL或HD风险之间存在关系。NHL和无烟烟草的使用之间没有联系。与正常体重（BMI 18.6-24.9）相比，BMI为30或更高并不意味着患NHL或HD的风险过高。我们的结论是吸烟和高BMI并不增加NHL和HD的风险。我们的研究结果之间的关系鼻烟浸渍和HD的持续时间需要进一步调查。(c)2005 Wiley-Liss，Inc.
in the search for risk factors involved in the etiology of lymphoproliferative malignancies there is still inconsistent evidence regarding effects of smoking tobacco, and the role of smokeless tobacco is poorly investigated. New evidence indicates that excess body weight increases the risk of NHL and HD. To determine if tobacco use of various forms and high Body Mass Index (BMI) affect the occurrence of these neoplasms, we conducted a prospective cohort study on over 330,000 Swedish construction workers included in the Construction Industry Working Environment and Health program. Information on smoking, snuff dipping, height and weight was gathered by self administered questionnaires together with personal interviews. Cancer incidence was ascertained through the year 2000 by record linkage to the nationwide Swedish Cancer Registry, Migration Registry and Cause of Death Registry. At the end of follow up, 1,309 subjects had been diagnosed with NHL (including chronic lymphocytic leukemia) and 205 with HD respectively. Age adjusted incidence rate ratios were computed using Cox proportional Hazard regression modeling. Smoking cigarette, pipe or cigar was not associated with NHI, or HI). There was no evidence indicating a relation between quantity and duration of smoking and NHL or HD risk. No link was found between NHL and usage of smokeless tobacco. Having a BMI of 30 or higher did not convey excess risk of developing NHL or HD compared to normal weight (BMI 18.6-24.9). We conclude that tobacco smoking and high BMI do not entail an increased risk of NHL and HD. Our findings of a relation between the duration of snuff dipping and HD need further investigation. (c) 2005 Wiley-Liss, Inc.