Relationship Between Coronary Arterial Remodeling, Fibrous Cap Thickness and High-Sensitivity C-Reactive Protein Levels in Patients With Acute Coronary Syndrome
Relationship Between Coronary Arterial Remodeling, Fibrous Cap Thickness and High-Sensitivity C-Reactive Protein Levels in Patients With Acute Coronary Syndrome
复制标题
DOI：
10.1253/circj.cj-08-0968
复制
发表时间：
2009-07-01
影响因子：
3.3
通讯作者：
Akasaka, Takashi
中科院分区：
文献类型：
--
作者：
Kashiwagi, Manabu;Tanaka, Atsushi;Akasaka, Takashi
背景：薄帽纤维粥样硬化（TCFA）是公认的急性冠状动脉综合征（ACS）的前驱病变。正性重构（PR）是ACS患者动脉重构的主要模式。本研究的目的是评估ACS患者冠状动脉重构、纤维帽厚度和高敏C反应蛋白（hs-CRP）浓度之间的关系。通过血管内超声评估罪犯斑块的动脉重塑，并通过光学相干断层扫描测量纤维帽厚度。重建指数（RI）以病变除以参考外弹力膜横截面积计算，PR定义为RI > 1.05（PR组）。TCFA在PR组中的发生率高于中度和负性重构（IR/NR）组（59%比17%，P
Background: Thin-capped fibroatheroma (TCFA) is a recognized precursor lesion for acute coronary syndrome (ACS). Positive remodeling (PR) is the predominant pattern of arterial remodeling in patients with ACS. The aim of this study was to evaluate the relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein (hs-CRP) concentration in patients with ACS.Methods and Results: The 47 consecutive ACS patients were enrolled in this study. Arterial remodeling of culprit plaque was assessed by intravascular ultrasound, and fibrous cap thickness was measured by optical coherence tomography. The remodeling index (RI) was calculated as lesion divided by the reference external elastic membrane cross-sectional area, and PR was defined as RI > 1.05 (PR group). TCFA were observed more frequently in the PR group than in the intermediate and negative remodeling (IR/NR) groups (59% vs 17%, P