Exclusive detection of cerebral hemodynamics in functional near-infrared spectroscopy by reflectance modulation of the scalp surface
Exclusive detection of cerebral hemodynamics in functional near-infrared spectroscopy by reflectance modulation of the scalp surface
复制标题
通过头皮表面反射调制在功能性近红外光谱中独家检测脑血流动力学
DOI：
10.1117/1.jbo.25.8.087001
复制
发表时间：
2020
影响因子：
3.5
通讯作者：
Yamada Toru
中科院分区：
文献类型：
--
作者：
Kawaguchi Hiroshi;Tanikawa Yukari;Yamada Toru
意义：功能性近红外光谱（fNIRS）是一种检测与大脑皮质神经激活相关的局部血流动力学反应的技术。由于头皮血流动力学变化而导致的吸收变化会导致fNIRS测量中相当大的信号污染。提取脑组织中的血流动力学变化的方法是需要可靠的fNIRS measurement.Aim：专门检测脑功能的血流动力学变化，我们开发了一种fNIRS技术，利用反射调制的头皮surface.Approach：所提出的方法的理论可行性证明了光传播的模拟计算。通过体模实验和模拟人体fNIRS实验的脑激活模拟，验证了该方法的可行性。结果：模拟计算表明，头皮表面的反射调制改变了头皮的部分光程长度。在体模实验中，仅使用测量数据，通过所提出的方法成功地减小了表面层吸收变化的影响。所提出的方法是适用于人体实验的标准设计，在一个可接受的实验时间框架内实现统计学意义。结论：去除头皮血流动力学的影响所提出的技术将提高fNIRS数据的质量，特别是在新生儿和婴儿的测量，通常需要一个密集的optode安排。
Significance:Functional near-infrared spectroscopy (fNIRS) is a technique for detecting regional hemodynamic responses associated with neural activation in the cerebral cortex. The absorption changes due to hemodynamic changes in the scalp cause considerable signal contamination in the fNIRS measurement. A method for extracting hemodynamic changes in the cerebral tissue is required for reliable fNIRS measurement.Aim:To exclusively detect cerebral functional hemodynamic changes, we developed an fNIRS technique using reflectance modulation of the scalp surface.Approach:The theoretical feasibility of the proposed method was proven by a simulation calculation of light propagation. Its practical feasibility was evaluated by a phantom experiment and brain activation simulation mimicking human fNIRS experiments.Results:The simulation calculation revealed that the partial path length of the scalp was changed by reflectance modulation of the scalp surface. The influence of absorption change in the superficial layer was successfully reduced by the proposed method, using only measurement data, in the phantom experiment. The proposed method was applicable to human experiments of standard designs, achieving statistical significance within an acceptable experimental time-frame.Conclusions:Removal of the scalp hemodynamic effect by the proposed technique will increase the quality of fNIRS data, particularly in measurements in neonates and infants that typically would require a dense optode arrangement.