Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia
Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia
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DOI：
10.5588/ijtld.12.0843
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发表时间：
2013-06-01
影响因子：
4
通讯作者：
van Ingen, J.
中科院分区：
文献类型：
--
作者：
Jankovic, M.;Samarzija, M.;van Ingen, J.
环境：非结核分枝杆菌（NTM）在Croatia.Objective的临床相关性是未知的：估计NTM的隔离率，记录地理差异，并评估肺NTM疾病的负担在Croatia.DESIGN：全国范围内的回顾性队列研究，所有克罗地亚居民与NTM分离培养在2006年至2010年期间。美国胸科学会的微生物学标准被用来建立一个实验室为基础的情况下定义的可能和可能的NTM diseases.RESULTS：1187个人与肺NTM分离株，8.6%符合可能和5.5%符合可能的疾病标准。我们估计可能的肺NTM疾病的年发病率为0.23/10万人口。沿海地区的年发病率估计为0.35/10万，大陆地区为0.17/10万。克罗地亚沿海和大陆之间的物种分布不同。结论：地理位置对NTM的种类分布和可能的疾病有重要影响。与结核病相比，克罗地亚NTM肺病的总体负担仍然较低，但沿海地区的负担高于大陆地区。
SETTING: The clinical relevance of non-tuberculous mycobacteria (NTM) in Croatia is unknown.OBJECTIVE: To estimate the isolation rate of NTM, record geographical differences and assess the burden of pulmonary NTM disease in Croatia.DESIGN: Nationwide retrospective cohort study of all Croatian residents with NTM isolated by culture in the period from 2006 to 2010. Microbiological criteria of the American Thoracic Society were used to establish a laboratory-based case definition of possible and probable NTM disease.RESULTS: Of 1187 individuals with pulmonary NTM isolates, 8.6% met the possible and 5.5% met the probable disease criteria. We estimated an annual incidence of probable pulmonary NTM disease of 0.23 per 100 000 population. This estimated annual incidence was 0.35/100 000 in the coastal region and 0.17/100 000 in the continental region. Species distribution differed between coastal and continental Croatia. NTM isolation frequency increased over the study period.CONCLUSION: Geography plays an important role in NTM species distribution and possible disease. The overall burden of NTM pulmonary disease in Croatia is still low compared to that of tuberculosis, but it is higher in the coastal region compared to the continental region.