Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: a biochemical and molecular study.
Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: a biochemical and molecular study.
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DOI：
10.1016/j.etap.2014.12.008
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发表时间：
2015
影响因子：
4.3
通讯作者：
G. Sindhu;Emayavaramban Nishanthi;R. Sharmila
中科院分区：
文献类型：
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作者：
G. Sindhu;Emayavaramban Nishanthi;R. Sharmila
顺铂是一种广泛使用的抗癌药物，用于治疗各种癌症。剂量依赖性肾毒性是顺铂化疗的主要问题。顺铂引起的肾毒性导致肾脏抗氧化防御系统的耗竭。本研究旨在探讨香草酸对顺铂肾毒性的保护作用。在顺铂（7 mg/kg bw）单独给药的大鼠中，观察到血清肌酐、血尿素氮、血清尿酸水平升高和抗氧化状态降低，作为肾毒性的指标。当与顺铂单独处理的动物相比时，用香草酸（50 mg/kg和100 mg/kg）预处理的动物恢复了升高的肾功能标志物水平，并将抗氧化状态降低至接近正常。顺铂诱导的脂质过氧化反应显着减少口服香草酸在高剂量。本研究的结果表明香草酸是一种潜在的抗氧化剂，可以减少顺铂的肾毒性，并可以作为癌症化疗的联合方案。
Cisplatin is one of the extensively used anticancer drugs against various cancers. Dosage dependent nephrotoxicity is the major problem in cisplatin chemotherapy. Cisplatin induced nephrotoxicity results in the depletion of renal antioxidant defence system. Our present study is aimed to investigate the nephroprotective effect of vanilic acid to against cisplatin induced nephrotoxicity in male wistar rats. Elevated levels of serum creatinine, blood urea nitrogen, serum uric acid and reduced antioxidant status were observed as indicatives of nephrotoxicity in cisplatin (7 mg/kg bw) alone administered rats. Animals which are pre-treated with vanillic acid (50 mg/kg and 100 mg/kg) restored the elevated levels of renal function markers and reduced antioxidant status to near normalcy when compared to cisplatin alone treated animals. Cisplatin induced lipid peroxidation was markedly reduced by oral administration of vanillic acid at a high dose. The findings in the present study suggest that vanillic acid is a potential antioxidant that reduce cisplatin nephrotoxicity and can be as a combinatorial regimen in cancer chemotherapy.