Strategies to regenerate hair cells: Identification of progenitors and critical genes
Strategies to regenerate hair cells: Identification of progenitors and critical genes
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DOI：
10.1016/j.heares.2007.08.007
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发表时间：
2008-02-01
期刊：
影响因子：
2.8
通讯作者：
Malgrange, Brigitte
中科院分区：
文献类型：
--
作者：
Breuskin, Ingrid;Bodson, Morgan;Malgrange, Brigitte
耳聋通常是由内耳听觉部分的感觉细胞和/或神经元的损伤引起的。目前还没有旨在阻止或逆转听力损失进展的治疗方法。开发治疗感音神经性耳聋的一个关键目标是确定替代丢失的毛细胞的策略。在两栖动物和鸟类中，所有内耳感觉毛细胞在受伤后自发再生。相比之下，在哺乳动物的耳蜗里，毛细胞只在胚胎发育过程中产生。为了证明内源性祖细胞的持久性，已经进行了许多研究。本文首先综述了自发毛细胞的存在以及在Corti器官中发现的Nestin阳性前体细胞。再生毛细胞的第二种方法是寻找对毛细胞分化至关重要的基因。本文还将重点介绍胚胎毛细胞形成的关键基因，如细胞周期相关蛋白、Atoh1基因和Notch信号通路。了解毛细胞产生的机制是确定治疗策略以再生成熟内耳毛细胞的基本前提。(C)2007 Elsevier B.V.保留所有权利。
Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the auditory part of the inner ear. There are currently no treatments designed to halt or reverse the progression of hearing loss. A key goal in developing therapy for sensorineural deafness is the identification of strategies to replace lost hair cells. In amphibians and birds, a spontaneous post-injury regeneration of all inner ear sensory hair cells occurs. In contrast, in the mammalian cochlea, hair cells are only produced during embryogenesis.Many studies have been carried out in order to demonstrate the persistence of endogenous progenitors. The present review is first focused on the occurrence of spontaneous supernumerary hair cells and on nestin positive precursors found in the organ of Corti. A second approach to regenerating hair cells would be to find genes essential for their differentiation. This review will also focus on critical genes for embryonic hair cell formation such as the cell cycle related proteins, the Atoh1 gene and the Notch signaling pathway. Understanding mechanisms that underlie hair cell production is an essential prerequisite to defining therapeutic strategies to regenerate hair cells in the mature inner ear. (c) 2007 Elsevier B.V. All rights reserved.