Cerebellar Gray Matter Density in Females With ADHD Combined Type: A Cross-Sectional Voxel-Based Morphometry Study
Cerebellar Gray Matter Density in Females With ADHD Combined Type: A Cross-Sectional Voxel-Based Morphometry Study
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DOI：
10.1177/1087054710366421
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发表时间：
2011-07-01
影响因子：
3
通讯作者：
Fernandez Bouzas, Antonio
中科院分区：
文献类型：
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作者：
Almeida Montes, Luis Guillermo;Ricardo-Garcell, Josefina;Fernandez Bouzas, Antonio
背景：MRI研究显示ADHD患者小脑体积减小。然而，这些研究大多是在男孩身上进行的，其中许多人服用了兴奋剂。因此，未接受药物治疗的非白人女孩在此类MRI研究中的代表性不足。目的：本研究的目的是比较未服药的非白人女性儿童、青少年和诊断为ADHD混合型（ADHD- c）的成人与健康对照者小脑半球灰质（GM）的密度。方法：对11名西班牙裔未服药的ADHD-C儿童（6-10岁）、8名西班牙裔青少年（14-17岁）、10名西班牙裔成年人（25-35岁）和各自的健康对照组进行mri检查。采用基于体素的形态测量法进行图像处理和统计分析，采用DARTEL算法改善空间归一化。结果：女性儿童、青少年和成人ADHD-C患者小脑右半球GM密度降低。结论：这些发现表明，未接受药物治疗的西班牙裔ADHD-C女孩的右小脑半球存在一种从儿童期到成年期的解剖异常。（美国医学杂志，2011;15(5):368-381）
Background: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies. Objective: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls. Method: MRIs were performed on 11 Hispanic unmedicated ADHD-C children (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization. Results: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C. Conclusions: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood. (J. of Att. Dis. 2011; 15(5) 368-381)