Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats
Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats
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DOI：
10.1016/s0899-9007(97)00471-1
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发表时间：
1998-03-01
期刊：
影响因子：
4.4
通讯作者：
Galbavy, S
中科院分区：
文献类型：
--
作者：
Bobek, P;Ozdin, L;Galbavy, S
以断奶雄性Wistar大鼠为研究对象，研究了日粮中平菇的剂量（1.0、2.5和5.0%）和施用时间（8、16、28和52周）对血液和身体器官中胆固醇积累的影响。血清和身体器官中胆固醇的降低与食用量有关。饲养8周和28周时，食用菌剂量与胆固醇水平呈负相关（r分别为-0.9821和-0.9803,P < 0.02）。1%剂量的平菇对血清和身体器官的胆固醇水平没有影响。在所有时期，5%的平菇剂量可显著降低血清（31-46%）和肝脏（25-30%）的胆固醇水平。极低密度脂蛋白（VLDL）中的胆固醇含量也在这个水平上降低。在实验末期，最高剂量的平菇诱导红细胞共轭二烯水平降低，肝脏还原性谷胱甘肽水平升高，并刺激肝脏过氧化氢酶和谷胱甘肽过氧化物酶的活性。(C) Elsevier Science Inc., 1998。
The effect of the dose of oyster mushroom in the diet (1.0, 2.5, and 5.0%) and of the period of application (8, 16, 28, and 52 wk) on cholesterol accumulation in blood and body organs was studied in weanling male Wistar rats fed a diet containing 0.3% cholesterol. Reduction of cholesterol in serum and body organs was found to be dependent on the amount of dietary oyster mushroom administered. A negative correlation between the mushroom dose and cholesterol level was found after 8 and 28 wk of feeding (r = -0.9821 and -0.9803, respectively; P < 0.02 for both cases). The dose of 1% oyster mushroom did not affect cholesterol levels in serum or body organs. A significant reduction of cholesterol levels was observed in serum (31-46%) and liver (25-30%) at a dose of 5% of oyster mushroom for all periods. Reduced cholesterol content in very low-density lipoproteins (VLDL) was also observed at this level. The highest dose of oyster mushroom induced a decrease in conjugated diene levels in erythrocytes and an increase in the levels of reduced glutathione in the liver and stimulated the activities of catalase and glutathione peroxidase in the liver in the final period of the experiment. (C) Elsevier Science Inc. 1998.