The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease
The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease
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DOI：
10.1016/j.jacc.2016.09.972
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发表时间：
2016-12-27
影响因子：
24
通讯作者：
Dyck, Jason R. B.
中科院分区：
文献类型：
--
作者：
Ussher, John R.;Elmariah, Sammy;Dyck, Jason R. B.
心脏能量代谢紊乱是许多心血管疾病的主要原因。此外，与心血管疾病（CVD）相关的合并症可改变全身和心肌代谢，通常导致心脏功能和健康结局恶化。最先进的代谢组学技术使我们能够测量生物液体或活检中的数千种代谢物，为我们提供个体患者的代谢指纹。这些代谢特征可以作为诊断和/或预后工具，有可能显着改变CVD的管理。在此，作者回顾了代谢组学如何帮助解释扰动的代谢过程，以及这如何提高我们理解缺血性心脏病，动脉粥样硬化和心力衰竭的病理学的能力。总之，代谢组学与其他“组学”平台的整合将使我们能够深入了解代谢物，蛋白质，基因和疾病状态的病理生理相互作用，同时推进个性化医疗。(C)2016年由美国心脏病学会基金会。
Perturbations in cardiac energy metabolism are major contributors to a number of cardiovascular pathologies. In addition, comorbidities associated with cardiovascular disease (CVD) can alter systemic and myocardial metabolism, often contributing to the worsening of cardiac function and health outcomes. State-of-the-art metabolomic technologies give us the ability to measure thousands of metabolites in biological fluids or biopsies, providing us with a metabolic fingerprint of individual patients. These metabolic profiles may serve as diagnostic and/or prognostic tools that have the potential to significantly alter the management of CVD. Herein, the authors review how metabolomics can assist in the interpretation of perturbed metabolic processes, and how this has improved our ability to understand the pathology of ischemic heart disease, atherosclerosis, and heart failure. Taken together, the integration of metabolomics with other "omics" platforms will allow us to gain insight into pathophysiological interactions of metabolites, proteins, genes, and disease states, while advancing personalized medicine. (C) 2016 by the American College of Cardiology Foundation.