DNA-capped nanoparticles designed for doxorubicin drug delivery
DNA-capped nanoparticles designed for doxorubicin drug delivery
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DOI：
10.1039/c0cc04916f
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Dabrowiak, James C.
中科院分区：
文献类型：
--
作者：
Alexander, Colleen M.;Maye, Mathew M.;Dabrowiak, James C.
抗癌药物多柔比星（DOX）被装载到DNA覆盖的金纳米粒子（AuNP）上，设计用于特定的DOX嵌入。通过监测DNA解链温度、AuNP等离子体共振最大值和流体动力学半径增加作为[DOX]/[DNA]比的函数来确认药物结合。证实了药物释放到靶DNA的能力。
The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.