Interleukin-12 as an adjuvant for induction of protective antibody responses.
Interleukin-12 as an adjuvant for induction of protective antibody responses.
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DOI:
10.1016/j.cyto.2010.06.011
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发表时间:
2010-10
期刊:
影响因子:
3.8
通讯作者:
Metzger, Dennis W.
中科院分区:
文献类型:
--
作者:
Metzger, Dennis W.
Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response are summarized in this review.
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影响因子:
15.3
作者:
Braun, M C;He, J;Wu, C Y;Kelsall, B L
通讯作者:
Kelsall, B L
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DOI:
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发表时间:
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期刊:
The Journal of experimental medicine
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