Interleukin-12 as an adjuvant for induction of protective antibody responses.

Interleukin-12 as an adjuvant for induction of protective antibody responses.
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DOI:
10.1016/j.cyto.2010.06.011
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发表时间:
2010-10
期刊:
影响因子:
3.8
通讯作者:
Metzger, Dennis W.
Metzger, Dennis W.
中科院分区:
医学3区
文献类型:
--
作者:
Metzger, Dennis W.

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白细胞介素(IL)-12是一种关键的细胞因子,强烈刺激Th 1相关的细胞免疫。现在认识到,IL-12还激活对T依赖性和T非依赖性抗原的体液免疫。这对于利用IL-12作为疫苗佐剂以保护免受各种细菌和病毒病原体,特别是在肺中具有相当大的兴趣。研究IL-12介导的保护性抗体反应的效果进行了总结。
Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response are summarized in this review.
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