Feline Drug Metabolism and Disposition Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms
Feline Drug Metabolism and Disposition Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms
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DOI：
10.1016/j.cvsm.2013.05.002
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发表时间：
2013-09-01
影响因子：
1.9
通讯作者：
Court, Michael H.
中科院分区：
文献类型：
--
作者：
Court, Michael H.
虽然人们普遍认为猫对某些药物的反应与其他伴侣动物物种不同，但对这些差异的原因知之甚少。本文评估了已发表的证据，改变猫的药物作用，重点是猫，狗和人类之间的药代动力学差异，以及这些差异的分子机制。需要更多的工作来更好地了解猫的药物代谢和处置差异，从而使现有药物的处方更加合理，并为这一物种开发更安全的药物。
Although it is widely appreciated that cats respond differently to certain drugs compared with other companion animal species, the causes of these differences are poorly understood. This article evaluates published evidence for altered drug effects in cats, focusing on pharmacokinetic differences between cats, dogs, and humans, and the molecular mechanisms underlying these differences. More work is needed to better understand drug metabolism and disposition differences in cats, thereby enabling more rational prescribing of existing medications, and the development of safer drugs for this species.