Evaluation of a "nude" mouse-human tumor panel as a predictive secondary screen for cancer chemotherapeutic agents.
Evaluation of a "nude" mouse-human tumor panel as a predictive secondary screen for cancer chemotherapeutic agents.
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对“裸”小鼠-人肿瘤组作为癌症化疗药物的预测性二次筛选的评估。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
D. Berd
中科院分区：
文献类型：
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作者：
R. Bellet;V. Danna;M. Mastrangelo;D. Berd
将9个已建立的异种移植到C57 BL/6“裸”小鼠中的人黑素瘤组织培养细胞系暴露于4种已知对人黑素瘤具有临床活性的化疗剂中。已知两种治疗剂，1，3-双（2-氯乙基）-1-亚硝基脲（BCNU）和5-（3，3-二甲基-1-三嗪基）咪唑-4-甲酰胺（DTIC）对人黑素瘤有活性;已知另外两种，阿霉素和5-氮杂胞苷无活性。无菌生理盐水作为对照剂。在2个细胞系异源移植中，对照肿瘤自发消退。在7个保留用于评价的细胞系中，4个对DTIC敏感，1个对BCNU敏感，没有一个对阿霉素或5-氮杂胞苷敏感。这些数据表明，裸鼠-人肿瘤模型可能是癌症化疗药物的预测性二次筛选。
Nine established human melanoma tissue-cultured cell lines heterotransplanted in C57BL/6 "nude" mice were exposed to each of 4 chemotherapeutic agents of known clinical activity against human melanoma. Two of the therapeutic agents, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 5-(3,3-dimethyl-1-triazino) imidazole-4-carboxamide (DTIC), are known to be active against human melanoma; the other two, adriamycin and 5-azacytidine, are known to be inactive. Sterile saline served as a control agent. In 2 cell line heterotransplants, the control tumor spontaneously regressed. Of the 7 cell lines that remained for evaluation, 4 were sensitive to DTIC, 1 was sensitive to BCNU, and none was sensitive to adriamycin or 5-azacytidine. These data indicate that the nude mouse-human tumor model may be a predictive secondary screen for cancer chemotherapeutic agents.