Use of choroidal vascularity index for choroidal structural evaluation in smokers: an optical coherence tomography study
Use of choroidal vascularity index for choroidal structural evaluation in smokers: an optical coherence tomography study
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DOI：
10.1080/15569527.2020.1793162
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发表时间：
2020-07-14
影响因子：
1.6
通讯作者：
Can, Ertugrul
中科院分区：
文献类型：
--
作者：
Kocak, Nurullah;Yeter, Volkan;Can, Ertugrul
目的 使用谱域光学相干断层扫描 (SD-OCT) 比较吸烟者和健康非吸烟者的脉络膜血管指数 (CVI) 和脉络膜厚度 (CT)。方法 42 名无全身性疾病的吸烟者和 46 名年龄性别匹配的健康志愿者纳入研究。使用SD-OCT在鼻侧和颞侧方向测量中央凹处以及距中央凹中心1500μm间隔处的脉络膜厚度。使用 ImageJ 软件将脉络膜图像二值化并分割为管腔面积 (LA)、基质面积 (SA) 和总脉络膜面积 (TCA)。脉络膜血管指数计算为 LA 与 TCA 的比率。吸烟受试者根据暴露年包数分为三组：10-20包年、20-30包年和>30包年。进行亚组分析以评估 CT/CVI/LA/SA/TCA 与包装年数之间的关系。结果 吸烟者和非吸烟者的平均年龄分别为 43.1 +/- 7.26 岁和 41.82 +/- 9.92 岁（p = 0.51）。吸烟者的平均中心凹下脉络膜厚度为 301.57 +/- 55.04 μm，非吸烟者的平均中心凹下脉络膜厚度为 303.38 +/- 53.42 μm (p = 0.826)。中心凹下位置或从中心凹向鼻和颞方向间隔1500μm的CT值在各组之间没有观察到显着差异。吸烟者的 CVI (65.4 +/- 2.3%) 显着低于非吸烟者 (66.3 +/- 2.5%) (p = 0.021)。在亚组分析中，吸烟年数超过 20 包的受试者的 CVI 显着低于不吸烟者，但吸烟年数在 10-20 包年之间的受试者则不然。根据烟包年数测量，CVI 与吸烟之间存在负相关（r = -0.226，p = 0.04）。结论 与健康对照组相比，吸烟者的 CVI 显着降低。研究结果表明，CVI 可以成为评估吸烟者脉络膜血管变化的非侵入性工具。
Purpose To compare the choroidal vascularity index (CVI) and choroidal thickness (CT) in smokers and healthy non-smoking subjects using spectral-domain optical coherence tomography (SD-OCT). Methods Forty-two smokers with no systemic disorders and 46 age-sex matched healthy volunteers were included in the study. SD-OCT was used to measure choroidal thickness at the fovea and 1500 mu m intervals from the foveal centre in both nasal and temporal directions. Choroidal images were binarized and segmented to the luminal area (LA), stromal area (SA), and total choroidal area (TCA) using ImageJ software. The choroidal vascularity index was calculated as the ratio of LA to TCA. Smoking subjects were divided into three groups according to pack-year exposure: 10-20 pack-years, 20-30 pack-years, and >30 pack-years. Subgroup analysis was performed to evaluate the relationship between CT/CVI/LA/SA/TCA and pack-years. Results The mean age of the smokers and non-smokers was 43.1 +/- 7.26 years and 41.82 +/- 9.92 years, respectively (p = 0.51). The mean subfoveal choroidal thickness was 301.57 +/- 55.04 mu m in smokers and 303.38 +/- 53.42 mu m in non-smokers (p = 0.826). No significant difference was observed between groups for CT values in the subfoveal location or at 1500 mu m intervals in the nasal and temporal direction from the fovea. The CVI was significantly lower in smokers (65.4 +/- 2.3%) than in non-smokers (66.3 +/- 2.5%) (p = 0.021). In the subgroup analysis, subjects with >20 pack-years of smoking had a significantly lower CVI than non-smokers, but those between 10-20 pack-years did not. A negative correlation was found between the CVI and smoking, as measured by cigarette pack-years (r = -0.226,p = 0.04). Conclusion The CVI was significantly decreased in smokers compared to healthy controls. The study results suggest that the CVI could be a non-invasive tool for evaluating choroidal vascular changes in smokers.