Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-β1/2, MMP-9 and BDNF in a rat model
Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-β1/2, MMP-9 and BDNF in a rat model
复制标题
DOI：
10.3892/mmr.2017.7464
复制
发表时间：
2017-11-01
影响因子：
3.4
通讯作者：
Wang, Xiao-Jing
中科院分区：
文献类型：
--
作者：
Hu, Yuan;Tang, Jin-Shu;Wang, Xiao-Jing
姜黄素是一种具有抗突变、抗肿瘤、抗氧化和神经保护作用的天然产物。然而，据我们所知，姜黄素尚未被研究用于治疗腰椎间盘退变（LIDD）。本研究的目的是探讨姜黄素是否可以通过调节诱导型一氧化氮合酶（iNOS）、环氧合酶（考克斯）-2、转化生长因子（TGF）-β 1/ 2、基质金属蛋白酶（MMP）-9和脑源性神经营养因子（BDNF）的表达来减轻LIDD大鼠模型。本研究的结果表明，姜黄素预处理可以防止大鼠LIDD的发展。结果显示，姜黄素治疗显著降低了LIDD大鼠的白细胞介素（IL）-1 β和IL-6、iNOS、考克斯-2和MMP-9水平。此外，姜黄素治疗降低了TGF-β 1和TGF-β 2的mRNA表达水平，而增加了LIDD大鼠BDNF的mRNA表达水平。总之，目前的研究结果表明，姜黄素可能发挥保护作用，LIDD的发展，发挥其作用，通过调节诱导型一氧化氮合酶，考克斯-2，TGF-β 1/2，MMP-9和BDNF。
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta 1/ 2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD. The results of the present study suggest that pretreatment with curcumin can prevent the development of LIDD in rats. It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1 beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD. In addition, treatment with curcumin reduced the mRNA expression levels of TGF-beta 1 and TGF-beta 2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD. In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta 1/2, MMP-9 and BDNF.