HOMEOTIC GENE-FUNCTION IN THE MUSCLES OF DROSOPHILA LARVAE
HOMEOTIC GENE-FUNCTION IN THE MUSCLES OF DROSOPHILA LARVAE
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DOI：
10.1002/j.1460-2075.1986.tb04500.x
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发表时间：
1986-09-01
期刊：
影响因子：
11.4
通讯作者：
HOOPER, JE
中科院分区：
文献类型：
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作者：
HOOPER, JE
果蝇幼虫的节段肌肉系统由每节24-30块肌肉组成。在三个胸段和第一个和最后一个腹段中发现了独特的肌肉模式;其余的腹段共享相同的模式。超双胸（Ubx）的突变导致幼虫腹部节的肌肉模式向后胸的部分转化。胸部肌肉不受影响。在前两个腹部节段中，变化包括至少11块“腹部"肌肉的损失和11块”胸部"肌肉的增加。较少广泛的转变见于更后的腹部节段。前双胸、双胸、后双胸和双胸样突变也诱导幼虫肌肉组织的转化。每个等位基因组影响作为整个Ubx结构域的子集的结构域，但是这些结构域不限于区室或区段，并且可以延伸通过多达五个区段。在肌肉中，Ubx抗原的节段分布与受Ubx突变影响的节段相关。Ubx在中胚层和外胚层中的不同结构域认为，肌肉模式的节段多样性不是简单地由上覆表皮诱导的，并且中胚层中的Ubx功能是腹部节段正确发育所必需的。
The segmental musculature of Drosophila melanogaster larvae consists of 24-30 muscles per segment. Unique patterns of muscles are found in the three thoracic segments and the first and last abdominal segments; the remaining abdominal segments share the same pattern. Mutations in Ultrabithorax (Ubx) cause partial transformation of the muscle pattern of larval abdominal segments towards metathorax. The muscles of the thorax are not affected. In the first two abdominal segments the changes include the loss of at least 11 ''abdominal'' muscles and the gain of 11 ''thoracic'' muscles. Less extensive transformations are seen in more posterior abdominal segments. Anterobithorax, bithorax, postbithorax and bithoraxoid mutations also induce transformations of the larval musculature. Each allelic group affects a domain that is a subset of the entire Ubx domain but these domains are not restricted to compartments or segments and may extend through as many as five segments. In the muscles the segmental distribution of Ubx antigen correlates with the segments affected by Ubx mutations. The different domains of Ubx in mesoderm and ectoderm argue that the segmental diversity of the muscle pattern is not simply induced by the overlying epidermis and that Ubx function in the mesoderm is required for the correct development of abdominal segments.