AMYGDALA MODULATION OF HIPPOCAMPAL-DEPENDENT AND CAUDATE NUCLEUS-DEPENDENT MEMORY PROCESSES
AMYGDALA MODULATION OF HIPPOCAMPAL-DEPENDENT AND CAUDATE NUCLEUS-DEPENDENT MEMORY PROCESSES
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DOI：
10.1073/pnas.91.18.8477
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发表时间：
1994-08-30
影响因子：
11.1
通讯作者：
MCGAUGH, JL
中科院分区：
文献类型：
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作者：
PACKARD, MG;CAHILL, L;MCGAUGH, JL
这些实验研究了在线索或空间水迷宫任务训练后立即向杏仁核、海马或尾状核注射d-安非他明（10微克/0.5微升）对记忆的影响。在实验1中，大鼠接受了两项任务之一的八次试验训练，然后注射d-苯丙胺或盐水。24小时后测试保留。在空间任务，海马内，但不是尾状核内，注射d-安非他明促进保留。相比之下，在提示任务尾内，但不是海马内，注射d-安非他明促进保留。训练后杏仁核内注射d-安非他明增强了这两项任务的保持。在实验2中，利多卡因（2%的溶液，1.0 μ l）注射intraamygdally保留测试之前，并没有阻止训练后的d-安非他明的杏仁核内注射引起的记忆增强。这些发现（i）进一步证明了海马体和尾状核在不同形式的记忆中的作用是分离的，（ii）表明杏仁核的调节作用不仅限于水迷宫中空间和线索辨别所代表的两种不同形式的记忆中的任何一种，和（iii）与先前的研究结果一致，表明杏仁核对记忆储存的影响不是由位于杏仁核内的持久神经变化介导的。
These experiments investigated the effects, on memory, of injections of d-amphetamine (10 mu g/0.5 mu l) administered into the amygdala, hippocampus, or caudate nucleus immediately after training in cued or spatial water-maze tasks. In experiment 1, rats received an eight-trial training session on one of the two tasks followed by injections of d-amphetamine or saline. Retention was tested 24 hr later. On the spatial task, intrahippocampal, but not intracaudate, injections of d-amphetamine facilitated retention. In contrast, on the cued task intracaudate, but not intrahippocampal, injections of d-amphetamine facilitated retention. Posttraining intraamygdala injections of d-amphetamine enhanced retention of both tasks. In experiment 2, lidocaine (2% solution; 1.0 mu l) injected intraamygdally prior to the retention test did not block the memory enhancement induced by posttraining intraamygdala injections of d-amphetamine. The findings (i) provide further evidence of a dissociation between the roles of the hippocampus and caudate nucleus in different forms of memory, (ii) indicate that the modulatory role of the amygdala is not limited to either of the two different forms of memory represented in spatial and cued discriminations in a water maze, and (iii) are consistent with previous findings indicating that amygdala influences on memory storage are not mediated by lasting neural changes located within the amygdala.