Linkage of human keratin genes.
Linkage of human keratin genes.
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人类角蛋白基因的连锁。
DOI：
10.1159/000132253
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Savtchenko,ES
中科院分区：
文献类型：
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作者：
Blumenberg,M;Savtchenko,ES
在蛋白质的中间丝家族中可以区分两个角蛋白家族，I型和II型，并且人类基因组中至少有20个基因编码20种已知的人类角蛋白。在上皮中间丝，角蛋白从两个家庭似乎是协调表达。我们已经筛选了人类基因组DNA库，并确定了几个案件的同源和异源角蛋白基因对之间的联系。发现编码I型角蛋白的基因与编码II型角蛋白的基因相关联。在编码I型角蛋白的同源基因和编码II型角蛋白的基因之间也发现了连锁。此外，我们发现富含甘氨酸的角蛋白编码基因与不含富含甘氨酸区域的角蛋白编码基因相关。我们的研究结果提出了所有角蛋白基因都在人类基因组的单个区域中连接的可能性。
Two families of keratins, type I and type II, can be distinguished within the intermediate filament family of proteins, and at least 20 genes in the human genome code for the 20 known human keratin proteins. In epithelial intermediate filaments, keratins from both families appear to be coordinately expressed. We have screened a library of human genomic DNA and have identified several cases of linkage among homologous and heterologous pairs of keratin genes. Genes coding for type I keratins were found linked to those coding for type II keratins. Linkage was discovered also among homologous genes coding for type I keratins and among genes encoding type II keratins. In addition, we found genes coding for glycine-rich keratins linked to genes coding for those that do not contain glycine-rich regions. Our results raise the possibility that all keratin genes are linked in a single region of the human genome.