Observations of the effect of atmospheric processes on the genotoxic potency of airborne particulate matter
Observations of the effect of atmospheric processes on the genotoxic potency of airborne particulate matter
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DOI：
10.1016/s1352-2310(02)00462-4
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发表时间：
2002-10-01
影响因子：
5
通讯作者：
Poulsen, MWB
中科院分区：
文献类型：
--
作者：
Feilberg, A;Nielsen, T;Poulsen, MWB
本研究探讨了城市和半农村大气中多环芳烃(PAH)，包括苯并(A)芘(BaP)和硝基多环芳烃(NPAH)的发生与遗传毒性的关系。沙门氏菌/微粒体法已被用作基因毒性效力的衡量标准。我们发现，BaP/致突变性和PAH/致突变性的比率是高度可变的。导致这种变化的过程是诱变剂的形成和降解以及来自高度工业化地区的污染气团的输送，来自中欧的气团被证明高度富含诱变剂以及多环芳烃和硝基多环芳烃。然而，当这些气团与当地城市空气混合时，诱变活性比多环芳烃水平要高得多。多环芳烃/致突变比的变化部分可以用光化学转化来解释。由于BaP过去一直被用作空气中颗粒物致癌风险的指标，因此建议必须重新评估空气污染的致癌风险。(C)2002爱思唯尔科学有限公司。保留所有权利。
In this study, the relationship between genotoxic potency and the occurrence of polycyclic aromatic hydrocarbons (PAH), including benzo(a)pyrene (BaP), and nitro-PAH in urban and semi-rural air masses has been investigated. The Salmonella/microsome assay has been used as a measure of genotoxic potency. We find that the ratios of BaP/ mutagenicity and PAH/mutagenicity are highly variable. The processes responsible for the variation are formation and degradation of mutagens and transport of polluted air masses from heavily industrialized regions, Air masses from Central Europe are shown to be highly enriched in mutagens as well as in PAH and nitro-PAH. However, the mutagenic activity is much more elevated than the PAH levels when these air masses are mixed with local urban air. Part of the variation in the PAH/mutagenicity ratio can be explained by photochemical transformation. Since BaP has been used in the past as an indicator of the carcinogenic risk of airborne particles, it is suggested that the cancer risk of air pollution has to be re-evaluated. (C) 2002 Elsevier Science Ltd. All rights reserved.