The metabolism of biphenyl. III. Phenolic metabolites in the pig.
The metabolism of biphenyl. III. Phenolic metabolites in the pig.
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联苯的代谢。
DOI：
10.1111/j.1600-0773.1976.tb03194.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. R. Scheline
中科院分区：
文献类型：
--
作者：
T. Meyer;J. C. Larsen;E. V. Hansen;R. R. Scheline
采用气相色谱/质谱联用法和气相色谱联用技术，对联苯在公猪和母猪体内的酚类代谢产物进行了定性和定量的三甲基硅基醚分析。该异物主要代谢为单羟基联苯，少量代谢为二羟基联苯和三羟基联苯。尿液排泄是这些化合物从体内排出的唯一途径。给药后96小时，公猪的尿量回收率为服药量的44.8%，母猪为27.6%。男性和女性在服药后24小时内排出尿液中的主要代谢物。
The phenolic metabolites of biphenyl in both male and female pigs were qualitatively and quantitatively analysed as trimethylsilyl (TMS) ethers by combined gas chromatography/mass spectrometry and gas chromatography, respectively. This xenobiotic was metabolized mainly to mono–hydroxylated biphenyl, and in small amounts to di– and tri–hydroxylated biphenyls. Urinary excretion was the only route of elimination of these compounds from the body. The total urinary recovery in male pigs was 44.8 % of the dose 96 hrs after administration of the drug, and the corresponding value in female pigs was 27.6%. The main part of the urinary metabolites was excreted during the first 24 hrs after dosing in both sexes.