TROMSO HEART-STUDY - HIGH-DENSITY LIPOPROTEIN AND CORONARY HEART-DISEASE - PROSPECTIVE CASE-CONTROL STUDY
TROMSO HEART-STUDY - HIGH-DENSITY LIPOPROTEIN AND CORONARY HEART-DISEASE - PROSPECTIVE CASE-CONTROL STUDY
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DOI：
10.1016/s0140-6736(77)92274-7
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发表时间：
1977-01-01
期刊：
影响因子：
168.9
通讯作者：
MJOS, OD
中科院分区：
文献类型：
--
作者：
MILLER, NE;THELLE, DS;MJOS, OD
The relationship of future clinical coronary heart-disease (CHD) to plasma-high-density-lipoprotein (HDL)-cholesterol concentration was examined in a 2 yr case-control follow-up study of 6595 men aged 20-49 yr living in the municipality of Troms, Norway. Measurements were made of cholesterol concentration in lower-density (i.e., density < 1.063 g/ml) lipoproteins, plasma-triglycerides, systolic and diastolic blood-pressures, relative body-wt and cigarette consumption. Discriminant-function analysis showed that coronary risk was inversely related to HDL-cholesterol concentration and directly related to density < 1.063 cholesterol. These relationships were independent of each other and other measured variables, which showed no significant differences between cases and controls. HDL cholesterol made a 3-fold greater contribution to prediction of future CHD than did density < 1.063 cholesterol in this cohort of young men. A low HDL concentration is apparently a common antecedent of clinical CHD and important in accelerating progression of coronary atherosclerosis.
