Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana
Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana
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DOI：
10.4269/ajtmh.2001.65.33
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发表时间：
2001-07-01
影响因子：
3.3
通讯作者：
Mills, JN
中科院分区：
文献类型：
--
作者：
Douglass, RJ;Wilson, T;Mills, JN
新诺布雷病毒(SNV)是北美汉坦病毒肺综合征(HPS)的主要病原体，以鹿为宿主。为了更好地了解美国西部HPS的流行病学，我们在蒙大拿州的12个标记重新捕获网格上进行了为期6年的鹿鼠种群动态和SNV抗体流行率的研究。在1公顷的栅格上，每月鹿鼠的数量从0到超过170只不等。SNV抗体流行率高于美国其他地区的研究，平均为13%(0%至50%)，并在每年5、6月份达到顶峰。抗体阳性的小鼠年龄更大(体重更重)(78%的阳性鼠为成年人，而阴性鼠为52%)，而且更有可能是雄性鼠(阳性鼠为61%，阴性鼠为53.4%)。所有年龄质量等级的抗体阳性的鹿鼠比抗体阴性的小鼠有更高比例的疤痕。抗体阳性成年小鼠的逐月存活率与抗体阴性小鼠相似，但幼鹿抗体阳性小鼠的存活率低于抗体阴性的鹿小鼠。这是第一项明确表明SNV感染对鹿小鼠有害影响的研究。
Sin Nombre virus (SNV), hosted by the deer mouse (Peromyscus maniculatus), is the primary etiologic agent of Hantavirus pulmonary syndrome (HPS) in North America. To improve our understanding of the epidemiology of HPS in the western United States, we conducted studies of population dynamics and SNV antibody prevalence in deer mouse populations for 6 years on 12 mark-recapture grids in Montana. Monthly numbers of deer mice ranged from zero to over 170 on I-hectare grids. SNV antibody prevalence was higher than observed in studies in other parts of the United States, averaging 13% (0% to 50%), and peaking in May or June each year. Antibody-positive mice were older (heavier) (78% of positives were adults versus 52% of negatives) and more likely to be males (61% of positives versus 53.4% of negatives). A higher proportion of antibody-positive deer mice of all age-mass classes had scars than did antibody-negative mice. Month-to-month survivorship of antibody-positive adult mice was similar to that of antibody-negative mice, but survival of young antibody-positive deer mice was lower than antibody-negative deer mice. This is the first study to clearly suggest a detrimental effect of SNV infection on deer mice.