Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-β1 and Retinoic Acid Signaling
Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-β1 and Retinoic Acid Signaling
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DOI：
10.4049/jimmunol.0901823
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发表时间：
2010-03-15
影响因子：
4.4
通讯作者：
Shimizu, Akira
中科院分区：
文献类型：
--
作者：
Watanabe, Kakeru;Sugai, Manabu;Shimizu, Akira
IgA is a specific isotype required for mucosal immunity and is the most abundant Ab produced in vivo. Recently, several inductive signals for IgA class switch recombination have been identified; however, the molecular details of the action of these signals and the specific factors acting in B cells remain elusive. In this study, we show that combination of retinoic acid (RA) and TGF-beta 1 with other factors induced a much higher frequency of IgA-switched cells than reported previously. In addition, IgA production is severely impaired in Runx2-Runx3 double-deficient mice. In Runx2-Runx3-deficient B cells, both RA- and TGF-beta 1-dependent inductions of a germline transcription are completely blocked. These data suggest that Runx proteins play an essential role in IgA class switching acting downstream of RA and TGF-beta 1 signaling. The Journal of Immunology, 2010, 184: 2785-2792.
