Sonic hedgehog is required early in pancreatic islet development
Sonic hedgehog is required early in pancreatic islet development
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DOI：
10.1006/dbio.2002.0573
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发表时间：
2002-04-01
影响因子：
2.7
通讯作者：
Moss, LG
中科院分区：
文献类型：
--
作者：
diIorio, PJ;Moss, JB;Moss, LG
胰腺器官发生依赖于细胞自主信号和细胞外信号的复杂相互作用。我们证明了形态原sonic hedgehog （Shh）是斑马鱼胰腺发育所必需的。Shh及其信号通路的基因突变确定了这种依赖是内分泌特异性的，而不是外分泌性的。利用环巴胺抑制hedgehog信号，我们发现瞬时Shh信号在原肠胚形成过程中对于随后内胚层分化为胰岛组织是必要的。在发育后期还发现了第二种依赖刺猬的活性，可能类似于肠道内胚层中Shh直接定位胰腺发育的已知作用。Shh的早期作用可能是一个更普遍的过程的一部分，允许神经内分泌细胞起源于非神经外胚层来源的组织。(C) 2002 Elsevier Science （USA）。
Pancreatic organogenesis relies on a complex interplay of cell-autonomous and extracellular signals. We demonstrate that the morphogen sonic hedgehog (Shh) is required for pancreatic development in zebrafish. Genetic mutants of Shh and its signaling pathway establish this dependence as specific to endocrine, but not exocrine, pancreas. Using cyclopamine to inhibit hedgehog signaling, we show that transient Shh signaling is necessary during gastrulation for subsequent differentiation of endoderm into islet tissue. A second hedgehog-dependent activity occurring later in development was also identified and may be analogous to the known action of Shh in gut endoderm to direct localization of pancreatic development. The early action of Shh may be part of a more general process allowing neuroendocrine cells to originate in nonneuroectodermally derived tissues. (C) 2002 Elsevier Science (USA).