Weight loss and resting energy expenditure in patients with chronic hepatitis C before and during standard treatment
Weight loss and resting energy expenditure in patients with chronic hepatitis C before and during standard treatment
复制标题
DOI：
10.1016/j.nut.2011.08.010
复制
发表时间：
2012-06-01
期刊：
影响因子：
4.4
通讯作者：
Soares, Elza Cotrim
中科院分区：
文献类型：
--
作者：
Fioravante, Milena;Alegre, Sarah Monte;Soares, Elza Cotrim
目的：丙型肝炎病毒（HCV）感染是一个严重的全球性公共卫生问题。在临床研究中，11%至29%的患者接受聚乙二醇干扰素-α-2a/2b治疗后体重减轻。很少有报告试图解释这种体重减轻。本研究的目的是评估营养状况，身体成分，和静息能量消耗（REE）在慢性丙型肝炎患者治疗前和治疗过程中与聚乙二醇干扰素和利巴韦林。方法：这是一项前瞻性研究与丙型肝炎病毒患者的评价前后12周的治疗与聚乙二醇干扰素和利巴韦林。评估包括人体测量（体重、身高、体重指数和腰围），并通过生物电阻抗分析确定身体成分。用间接量热法测得每个个体的REE。为了比较两个治疗阶段，使用Wilcoxon检验。结果：治疗期间受试者体重明显减轻，体重指数明显下降。这种体重减轻伴随着体脂的显著减少，而无脂质量没有减少。有一个显着的减少，能量摄入的评估24小时回忆。然而，有没有变化，在REE和REE校正的无脂肪mass.Conclusion：我们的研究丙型肝炎治疗的患者表明，这些患者有显着的体重减轻，这是不相关的能量消耗的变化。然而，我们观察到能量摄入量显著下降，这表明可能需要采取干预措施来减少损害。(C)2012 Elsevier Inc. All rights reserved.
Objective: Infection with hepatitis C virus (HCV) is a serious public health problem worldwide. In clinical studies, weight loss has been reported in 11% to 29% of patients treated with pegylated interferon-alpha-2a/2b. Few reports have tried to explain such a weight loss. The aim of this study was to evaluate nutritional status, body composition, and resting energy expenditure (REE) in patients with chronic hepatitis C before and during treatment with pegylated interferon and ribavirin.Methods: This was a prospective study with the evaluation of patients with hepatitis C virus before and after 12 wk of treatment with pegylated interferon and ribavirin. The evaluation consisted of anthropometry (weight, height, body mass index, and waist circumference), and body composition was determined by bioelectrical impedance analysis. The REE of each individual was obtained by indirect calorimetry. To compare the two phases of treatment, the Wilcoxon test was used. The significance level was 5%.Results: Subjects had significant weight loss during treatment with a consequent decrease in body mass index. This weight decrease was accompanied by a significant decrease in body fat and no decrease in fat-free mass. There was a significant decrease in energy intake as assessed by 24-h recall. However, there was no change in REE and in REE corrected for fat-free mass.Conclusion: Our study of patients with hepatitis C treatment showed that these patients had significant weight loss and this was not associated with changes in energy expenditure. However, we observed a significant decrease in energy intake, pointing to a possible need for intervention measures to decrease the damage. (C) 2012 Elsevier Inc. All rights reserved.